166113-89-9Relevant academic research and scientific papers
Synthesis and Neurotropic Activity of Novel Condensed Cyclopentanopyrido[3',2':4,5]-Thieno[3,2-D]Pyrimidine Derivatives
Dabaeva,Bagdasaryan,Paronikyan,Dashyan, Sh. Sh.,Paronikyan,Nazaryan,Akopyan
, p. 707 - 713 (2020)
2-Oxo-2,5,6,7-tetrahydro-3-cyano-1H-cyclopenta[b]pyridine was used as the starting point to develop an accessible synthesis of condensed cyclopentanopyrido[3',2':4,5]thieno[3,2-d]pyrimidine derivatives. The neurotropic activity of these compounds was studied, and a number of them showed anticonvulsant activity as antagonism to corasol. Compound II, like diazepam, had anti-anxiety and activating effects, while the other compounds had sedative activity.
Regioselective synthesis of 5,6-polymethylene-3-cyanopyridine-2(1H)-thiones and fused heterocycles based on them
Rodinovskaya, L. A.,Belukhina, E. V.,Shestopalov, A. M.,Litvinov, V. P.
, p. 449 - 457 (2007/10/02)
Condensation of 2-hydroxymethylenecyclopentan-1-one or -cyclooctan-1-one sodium salts with cyanothioacetamide afforded 5,6-polymethylene-3-cyanopyridine-2(1H)-thiones which were regioselectively alkylated at the sulfur atom by alkyl halides.Derivatives of 3-cyanopyridine-2(1H)-thione and 2-alkylthio-3-cyanopyridine were used for regioselective synthesis of substituted heterocycles: 3-aminothienopyridines, pyridothienopyrimidines, and pyridothienooxazines. - Key words: fused heterocycles; 5,6-polymethylene-3-cyanopyridine-2(1H)-thiones; 2-alkylthio-3-cyanopyridines; 3-aminothienopyridines; pyridothienopyridines; pyridothienooxazines; regioselective synthesis.
