1661825-96-2Relevant academic research and scientific papers
Identification of a new bis-amino acid glycoside selectively toxic to multiple myeloma cells
Cheng, Chao-Ying,Feng, Yan-Yan,Zang, Yi,Li, Jia,He, Xiao-Peng,Chen, Guo-Rong
, p. 39 - 42 (2014)
A bis-triazolyl phenylalaninyl galactoside was synthesized by a two-fold click reaction between an azido phenylalanine and a di-O-propynyl galactoside. By a cytotoxicity assay the compound was determined to be selectively toxic for multiple myeloma (MM) among a series of cancer cell lines with no toxicity to a control cell line. A Western blot analysis suggested that this compound could potentiate the cleavage of poly ADP-ribose polymerase in MM cells, leading to apoptosis.
