1661847-01-3

Basic information

• Product Name: N-[(DIMETHYLAMINO)METHYLENE]-N'-(4-FLUOROPHENYL)THIOUREA
• Synonyms: N-[(DIMETHYLAMINO)METHYLENE]-N'-(4-FLUOROPHENYL)THIOUREA
• CAS NO: 1661847-01-3
• Molecular Formula: C10H12FN3S
• Molecular Weight: 225.29
• Mol File: 1661847-01-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-[(DIMETHYLAMINO)METHYLENE]-N'-(4-FLUOROPHENYL)THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(DIMETHYLAMINO)METHYLENE]-N'-(4-FLUOROPHENYL)THIOUREA(1661847-01-3)
• EPA Substance Registry System: N-[(DIMETHYLAMINO)METHYLENE]-N'-(4-FLUOROPHENYL)THIOUREA(1661847-01-3)

Safety Data

• Hazardous Substances Data: 1661847-01-3(Hazardous Substances Data)

Upstream product

• 459-05-2 (4-fluoro-phenyl)-thiourea 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Relevant articles and documents

Pharmacological investigation of quinoxaline-bisthiazoles as multitarget-directed ligands for the treatment of Alzheimer's disease

Alzheimer's disease (AD) is the most prevalent disease of old age leading to dementia. Complex AD pathogenesis involves multiple factors viz. amyloid plaque formation, neurofibrillary tangles and inflammation. Herein we report of a new series of quinoxaline-bisthiazoles as multitarget-directed ligands (MTDLs) targeting BACE-1 and inflammation concurrently. Virtual screening of a library of novel quinoxaline-bisthiazoles was performed by docking studies. The most active molecules from the docking library were taken up for synthesis and characterized by spectral data. Compounds 8a-8n showed BACE-1 inhibition in micro molar range. One of the compounds, 8n showed BACE-1 inhibition at IC50 of 3 ± 0.07 μM. Rat paw edema inhibition in acute and chronic models of inflammation were obtained at 69 ± 0.45% and 55 ± 0.7%, respectively. Compound 8n also showed noteworthy results in AlCl3 induced AD model. The treated rats exhibited excellent antiamnesic, antiamyloid, antioxidant, and neuroprotective properties. Behavioural parameters suggested improved cognitive functions which further validates the testimony of present study. Moreover, compound 8n was found to have inherent gastrointestinal safety. This new string of quinoxaline-bisthiazoles were identified as effective lead for the generation of potent MTDLs and compound 8n was found to showcase qualities to tackle AD pathogenesis.

New Synthesis of 1,2,4-Thiadiazoles

A new synthesis of 1,2,4-thiadiazoles has been developed.N'-(Thioaroyl)- (and N'-arylthiocarbamoyl-) N,N-dimethylamidines, which were prepared in excellent yields by reactions of thioamides (and thioureas) with N,N-dimethylalkanamide dimethyl acetals, rea