166194-56-5Relevant articles and documents
QUINOLINONE PYRIMIDINES COMPOSITIONS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
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Paragraph 0619; 0624; 0625, (2016/04/19)
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R6 are described herein.
Enzymatic Polyketide Chain Branching to Give Substituted Lactone, Lactam, and Glutarimide Heterocycles
Heine, Daniel,Bretschneider, Tom,Sundaram, Srividhya,Hertweck, Christian
supporting information, p. 11645 - 11649 (2016/02/19)
Polyketides typically result from head-to-tail condensation of acyl thioesters to produce highly functionalized linear chains. The biosynthesis of the phytotoxin rhizoxin, however, involves a polyketide synthase (PKS) module that introduces a δ-lactone ch
CHK-1 INHIBITORS
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Page/Page column 213, (2010/02/11)
Disclosed are novel inhibitors of Chk-1 and methods of using the same for therapy.