166196-73-2

Basic information

• Product Name: 2-(1H-pyrazol-5-yl)thiazole
• Synonyms: 2-(1H-pyrazol-5-yl)thiazole;2-(1H-Pyrazol-3-yl)thiazole
• CAS NO: 166196-73-2
• Molecular Formula: C₆H₅N₃S
• Molecular Weight: 151.189
• Mol File: 166196-73-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 154～156℃
• Boiling Point: 385.7°C at 760 mmHg
• Flash Point: 195.9°C
• Appearance: /
• Density: 1.387g/cm³
• Vapor Pressure: 8.29E-06mmHg at 25°C
• Refractive Index: 1.652
• CAS DataBase Reference: 2-(1H-pyrazol-5-yl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-pyrazol-5-yl)thiazole(166196-73-2)
• EPA Substance Registry System: 2-(1H-pyrazol-5-yl)thiazole(166196-73-2)

Safety Data

• Hazardous Substances Data: 166196-73-2(Hazardous Substances Data)

Usage

General Description

2-(1H-pyrazol-5-yl)thiazole is a chemical compound with the molecular formula C7H6N2S. It is a derivative of thiazole and contains a pyrazole ring. 2-(1H-pyrazol-5-yl)thiazole is often used as a building block in chemical synthesis and can be found in various pharmaceutical and agrochemical products. It may possess various biological activities and is considered a valuable intermediate for the synthesis of diverse organic compounds. Additionally, its structure and properties make it a potential candidate for further research and development in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C6H5N3S/c1-2-8-9-5(1)6-7-3-4-10-6/h1-4H,(H,8,9)

Upstream product

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• 912848-91-0 3-dimethylamino-1-(2-thiazolyl)-2-propen-1-one 
• 191729-27-8 3-(dimethylamino)-1-(thiazol-2-yl)prop-2-en-1-one 

Downstream Products

• 1599475-11-2 2,6-difluoro-N-(5-(3-(thiazol-2-yl)-1-vinyl-1H-pyrazol-5-yl)thiophen-2-yl)benzamide 
• 1599475-04-3 5-(1-ethyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)-N-(2,4,6-trifluorophenyl)thiophene-2-carboxamide 
• 1599475-03-2 N-(2,6-difluorophenyl)-5-(1-ethyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide 
• 1599475-02-1 5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)-N-(2,4,6-trifluorophenyl)thiophene-2-carboxamide 
• 1599475-01-0 N-(2,4-difluorophenyl)-5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide 
• 1599475-00-9 N-(2,6-difluorophenyl)-5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide 
• 1345118-91-3 N-[5-(1-methyl-3-(1,3-thiazol-2-yl)pyrazol-5-yl)(2-pyridyl)](2,6-difluorophenyl)carboxamide 
• 1361379-54-5 (2,6-difluorophenyl)[5-(1-methyl-3-(1,3-thiazol-2-yl)pyrazol-5-yl)(2-thienyl)]carboxamide 

Relevant articles and documents

PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE

The present invention provides compounds having a structure according to Formula (I) or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6, are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

PROCESS FOR PREPARING BICYCLIC COMPOUNDS

The present invention relates to a novel process for preparing compounds of formula (IA), which are potent and specific antagonists of corticotropin-releasing factor (CRF) receptors, from intermediate compounds of formula (I), by a coupling reaction catal