166248-41-5

Upstream product

• 166375-53-7 1.2;3.4-Di-O-isopropyliden-D-threit 
• 591-31-1 3-methoxy-benzaldehyde 
• 166248-39-1 (2S,3S)-1,4-Bis-(1,1,2-trimethyl-propoxy)-butane-2,3-diol 

Relevant academic research and scientific papers

Highly Diastereoselective Ring-Opening Reactions of Chiral Acetals with Secondary or Sterically Hindered Grignard Reagents

1,4-Di-tert-alkoxy-(2S,3S)-2,3-butanediols 2 were obtained from the reactions of 2S,3S-threitol bisketals with Grignard reagents.The reactions of benzylic acetals 3, prepared from 1,4-di-tert-alkoxy-(2S,3S)-2,3-butanediols and aromatic aldehydes, with aryl or secondary or sterically hindered Grignard reagents give the corresponding ring-opening products 4 in high diastereoselectivity.