166248-45-9Relevant academic research and scientific papers
Highly Diastereoselective Ring-Opening Reactions of Chiral Acetals with Secondary or Sterically Hindered Grignard Reagents
Yuan, Tien-Min,Yeh, Sue-Min,Hsieh, Yu-Tsai,Luh, Tien-Yau
, p. 8192 - 8196 (1994)
1,4-Di-tert-alkoxy-(2S,3S)-2,3-butanediols 2 were obtained from the reactions of 2S,3S-threitol bisketals with Grignard reagents.The reactions of benzylic acetals 3, prepared from 1,4-di-tert-alkoxy-(2S,3S)-2,3-butanediols and aromatic aldehydes, with aryl or secondary or sterically hindered Grignard reagents give the corresponding ring-opening products 4 in high diastereoselectivity.
