166249-11-2

Upstream product

• 166249-03-2 1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-thio-β-D-ribofuranosyl]uracil 
• 6741-73-7 1-(4-thio-β-D-ribofuransoyl)uracil 
• 166249-07-6 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-thiophen-2-yl)-3-(2-methoxy-ethoxymethyl)-1H-pyrimidine-2,4-dione 
• 166249-10-1 1-(5-O-trityl-2-deoxy-4-thio-β-D-erythro-pentofuranosyl)-3-(2-methoxyethoxymethyl)uracil 
• 166249-04-3 Thiocarbonic acid O-[(2R,3R,3aS,9aR)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-tetrahydro-4,6,8-trioxa-1-thia-5,7-disila-cyclopentacycloocten-3-yl] ester O-phenyl ester 
• 166249-06-5 3-(2-Methoxy-ethoxymethyl)-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-4,6,8-trioxa-1-thia-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione 
• 166249-05-4 1-[2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-thio-β-D-ribofuranosyl]uracil 

Relevant academic research and scientific papers

Synthesis and biological activity of sugar-fluorinated 2',3'-dideoxy-4'- thioribofuranosyl nucleosides

The efficient DAST fluorination of deoxy-4'-thiopyrimidine nucleosides is reported. The cytidine analogue 3b was marginally effective against HIV.

Facile fluorination of deoxy-4'-thiopyrimidine nucleosides with 'down' hydroxyl group retention of configuration after fluoride opening of the quaternized N3-MEM anhydronucleosides

Attempted fluorination of 1-(5-O-trityl-3-deoxy-4-thio-β-D-erythro-pentofuranosyl)-3-(2-methoxy ethoxymethyl)uracil (12) and 1-(5-O-trityl-2-deoxy-4-thio-β-D-erythro-pentofuranosyl)-3-(2-methoxy ethoxymethyl)uracil (14) with diethylaminosulfur trifluoride