166270-91-3Relevant academic research and scientific papers
New sulfanilamide derivatives incorporating heterocyclic carboxamide moieties as carbonic anhydrase inhibitors
Angeli, Andrea,Brovarets, Volodymyr,Capasso, Clemente,De Luca, Viviana,Geronikaki, Athina,Kartsev, Victor,Panchishin, Svitlana Y.,Petrou, Anthi,Pinteala, Mariana,Supuran, Claudiu T.,Vydzhak, Roman M.
, (2021/08/31)
Carbonic Anhydrases (CAs) are ubiquitous metalloenzymes involved in several disease conditions. There are 15 human CA (hCA) isoforms and their high homology represents a challenge for the discovery of potential drugs devoid of off-target side effects. For this reason, many synthetic and pharmacologic research efforts are underway to achieve the full pharmacological potential of CA modulators of activity. We report here a novel series of sulfanilamide derivatives containing heterocyclic carboxamide moieties which were evaluated as CA inhibitors against the physiological relevant isoforms hCA I, II, IX, and XII. Some of them showed selectivity toward isoform hCA II and hCA XII. Molecular docking was performed for some of these compounds on isoforms hCA II and XII to understand the possible interaction with the active site amino acid residues, which rationalized the reported inhibitory activity.
Synthesis of Some New Derivatives of Dithiene- and Oxathienecarboxylic Acids
Mamedov, V. A.,Sibgatullina, F. G.,Gubskaya, V. P.,Gainullin, R. M.,Shagidullin, R. R.,Il'yasov, A. V.
, p. 1029 - 1033 (2007/10/03)
Substituted anilides of 1,4-dithiene- and oxathienecarboxylic acids were synthesized.It was shown that the reaction of 3-phenyl-1,4-dithi-2-ene-2-carboxyl chloride with 2-aminopyridines, depending on the base used and the reaction conditions, leads to the
