166271-34-7Relevant academic research and scientific papers
METHOD FOR PREPARING SUBSTITUTED N-(3-AMINO-QUINOXALIN-2-YL)-SULFONAMIDES AND THEIR INTERMEDIATES N-(3-CHLORO-QUINOXALIN-2-YL)SULFONAMIDES
-
Page/Page column 23, (2012/05/05)
The present invention provides a new synthesis for preparing N-(3-amino-quinoxalin-2-yl)-sulfonamides of general formulae (I) or (I') and intermediates sulfonamides of formula (II) or (II'):
METHODS OF USING PI3K AND MEK MODULATORS
-
Page/Page column 300, (2008/06/13)
The invention provides methods of treating cancer with a combination of compounds which inhibit kinases, more specifically MEK and PI3K.
METHODS OF TREATING BY INHIBITING WITH QUINAXOLINE INHIBITORS OF PI3K-ALPHA
-
Page/Page column 433, (2008/12/08)
The present invention provides methods of treating cancer by administering a compound of Formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination with other cancer treatments.
QUINOXALINE COMPOUNDS AND USE THEREOF
-
Page/Page column 96, (2008/12/08)
The present invention is related to quinoxaline compounds of Formula (I) in particular for the treatment of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS AND METHODS OF THEIR USE
-
Page/Page column 238, (2010/11/27)
The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and glioblastomas, am
PYRAZINE DERIVATIVES AND USE AS PI3K INHIBITORS
-
Page/Page column 51-52, (2008/06/13)
The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
SYNTHESIS, STRUCTURE, AND CHEMICAL PROPERTIES OF SOME N-(3-CHLORO-2-QUINOXALYL)ARYLSULFONAMIDES
Litvinenko, S. V.,Savich, V. I.,Bobrovnik, L. D.
, p. 340 - 344 (2007/10/02)
We have developed a method for synthesis of N-(3-chloro-2-quinoxalyl)sulfonamides by reaction of 2,3-dichloroquinoxaline with substituted arylsulfonamides.Based on the IR spectra, we have established that in the solid state, the synthesized compounds exis
