166272-95-3Relevant academic research and scientific papers
Diethyl 2-oxopent-3-ynedioate: Synthesis and first cyclizations of a novel, reactive alkyne
Blitzke,Sicker,Wilde
, p. 236 - 238 (1995)
Diethyl 2-oxopent-3-ynedioate (3), the carbonyl homologue of diethyl acetylenedicarboxylate, is prepared by thermolysis of bis(ethoxalyl)methylenetriphenylphosphorane (2) and is found to be a reactive building block. Diels-Alder reaction of its alkyne unit with 1,3-diphenylisobenzofuran affords the cycloadduct 4, whereas reaction with binucleophiles such as ortho-XH-anilines (X = O,NH,S) leads to the incorporation of the oxoalkyne C3 -segment into the heterocycles 5-7.
