166303-32-8Relevant academic research and scientific papers
Allene-based Electrophile-mediated Cyclisations: Efficient Synthesis of Medium Ring Azacycles
Shaw, Robert W.,Gallagher, Timothy
, p. 3549 - 3556 (2007/10/02)
While AgI- and PdII-based electrophiles have limited application in cyclisation of allenic amines leading to 7-membered and larger azacycles, these rings may be obtained using iodine as the electrophilic trigger.Iodination of the N-b
RING-CLOSURE REACTIONS. XX. AN EFFICIENT SYNTHESIS OF MANY-MEMBERED AZACYCLOALKANES
Gargano, Patrizia,Mandolini, Luigi
, p. 31 - 34 (2007/10/02)
An efficient cyclization of N-tosyl-ω-bromoalkylamines to N-tosylazacycloalkanes in the presence of a combination of EtOK/K2CO3 in Me2SO solution is described.This base-solvent system permitted the high-dilution conditions favourable to cyclization to be attained with a conveniently high rate of feed of the bifunctional reactants into the reaction medium.Yields are very good for the large rings, and still satisfactory, although significantly lower, for the medium-sized rings.
