166315-81-7

Upstream product

• 154039-35-7 1-chloro-1-(3-trifluoromethylphenyl)ethane 
• 210840-49-6 O-{1-(3-trifluoromethylphenyl)ethyl}-acetohydroxamate 

Downstream Products

• 208196-07-0 (S)-O-[1-(3-trifluoromethylphenyl)ethyl]hydroxylamine 
• 208196-06-9 (R)-O-[1-(3-trifluoromethylphenyl)ethyl]hydroxylamine 
• 166313-51-5 ethyl {1,3-dimethyl-4-(α-methyl-3-trifluoromethyl-benzyloxyiminomethyl)pyrazole-5-yl} carboxylate 

Relevant academic research and scientific papers

Practical Asymmetric Synthesis of (S)-MA20565, a Wide-Spectrum Agricultural Fungicide

A practical asymmetric synthesis of a wide-spectrum agricultural fungicide, (S)-MA20565 (1), is described. The convergent synthesis was achieved starting from commercially available 3-(trifluoromethyl)aniline (7) in 44% overall yield through five steps and 2-bromobenzaldehyde (9) in 48% overall yield through four steps, respectively. (S)-O-[1-(3-Trifluoromethylphenyl)ethyl]hydroxylamine (2), a key intermediate of 1, was prepared via ruthenium(II)-catalyzed asymmetric transfer hydrogenation of 1-(3-trifluoromethylphenyl)ethanone (6) followed by chlorination using methanesulfonyl chloride and oxyamination using potassium acetohydroxamate with high level of stereocontrol.

OPTICALLY ACTIVE METHOXYIMINOACETAMIDE DERIVATIVES, PROCESS FOR THE PREPARATION OF THEM, INTERMEDIATES THEREFOR, AND PESTICIDES CONTAINING THEM AS THE ACTIVE INGREDIENT

An optically active methoxyiminoacetamide derivative represented by the following general formula (I) (in the above general formula, Ar represents an aryl group or a heteroaryl group, Y represents a hydrogen atom, a halogen atom, a C1-C4alkyl group, a C1-C4haloalkyl group, a C1-C4alkoxy group, a C1-C4haloalkoxy group, a C1-C4alkylthio group, a C2-C6alkynyloxy group, a cyano group, a nitro group or an aryl group and n is an integer of 1 to 3), wherein its angle of rotation shows a negative value in chloroform has markedly excellent activities as agricultural chemicals.

PROCESS FOR PRODUCING N-METHYL-METHOXYIMINOACETAMIDE DERIVATIVES AND INTERMEDIATES THEREOF

A method for producing an N-methyl-methoxyiminoacetamide derivative represented by the following general formula (I) (wherein R3represents a hydrogen atom or a group represented by a general formula -C(R4)(R5)-Ar (wherein