166319-04-6

Basic information

• Product Name: 2-Oxo-3-phenyl-5-methylisoxazolo<2,3-a>pyrimidine
• Synonyms: 2-Oxo-3-phenyl-5-methylisoxazolo<2,3-a>pyrimidine
• CAS NO: 166319-04-6
• Molecular Weight: 226.235
• Mol File: 166319-04-6.mol

Chemical Properties

• CAS DataBase Reference: 2-Oxo-3-phenyl-5-methylisoxazolo<2,3-a>pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxo-3-phenyl-5-methylisoxazolo<2,3-a>pyrimidine(166319-04-6)
• EPA Substance Registry System: 2-Oxo-3-phenyl-5-methylisoxazolo<2,3-a>pyrimidine(166319-04-6)

Safety Data

• Hazardous Substances Data: 166319-04-6(Hazardous Substances Data)

Upstream product

• 5436-21-5 acetylacetaldehyde dimethyl acetal 
• 2510-30-7 3-Amino-4-phenylisoxazol-5-one 

Relevant articles and documents

Synthesis and rearrangement of 2-oxo-3-phenylisoxazolo[2,3-a]pyrimidines

2-Oxo-3-phenylisoxazole[2,3-a]pyrimidine derivatives were synthesized by the reaction of 3-amino-4-phenyl-5-isoxazolone with malonaldehyde tetraacetal, 3-oxobutyraldehyde diacetal, 2,4-pentanedione, and 1-phenyl-1,3-butanedione. The regioselectivity of this reaction was determined by X-ray single crystal structural analysis. Upon heating either in water or in ethanol this bicyclic system underwent a ring opening, followed by decarboxylation to yield phenylpyrimidylmethanol and phenylpyrimidyl ethers. The structures of these 2-oxoisoxazolo[2,3-a]pyrimidines and the mechanism of their rearrangement is discussed.