166334-72-1Relevant academic research and scientific papers
Structure-based design of nonpeptidic HIV protease inhibitors from a cyclooctylpyranone lead structure
Romines,Watenpaugh,Howe,Tomich,Lovasz,Morris,Janakiraman,Lynn,Horng,Chong,Hinshaw,Dolak
, p. 4463 - 4473 (2007/10/03)
Recently, the novel cyclooctylpyranone HIV protease inhibitor 1 was identified in our labs, and an X-ray structure of this inhibitor complexed with HIV-2 protease was obtained. This crystal structure was used to develop two strategies for creating derivat
