166374-44-3

Upstream product

• 1385032-85-8 7-amino-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid dicyclohexylamine salt 
• 166581-61-9 7-amino-3-[(E)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid dicyclohexylamine salt 
• 1207515-78-3 C₁₃H₁₂N₃O₃S₂^(1-)*Na⁽¹⁺⁾ 

Downstream Products

• 1385032-85-8 7-amino-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid dicyclohexylamine salt 
• 166581-61-9 7-amino-3-[(E)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid dicyclohexylamine salt 

Relevant academic research and scientific papers

3-ALKENYLCEPHEM COMPOUNDS AND PROCESS FOR PRODUCTION THEREOF

A 3-alkenylcephem compound of the formula (1) wherein R 1 is benzyl or phenoxymethyl, R 2 , R 3 and R 4 are alike or different and are each a hydrogen atom, C 1-10 alkyl, C 4-8 cycloalkyl or aryl C 1-3 alkyl substituted or unsubstituted with C 1-4 alkyl, R 2 and R 3 , when taken together, form a group -(CH 2 ) 1 X m (CH 2 ) n - substituted or unsubstituted with C 1-4 alkyl at an optional position, X is an oxygen atom or group -N(R 5 )-, 1 is 0 to 3, m is 0 or 1, n is an integer of 2 to 4, R 5 is a hydrogen atom or C 1-4 alkyl.

PROCESS FOR PRODUCTION OF 3-ALKENYLCEPHEM COMPOUNDS

A process for preparing 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) and an alkali metal salt thereof, said acid and said salt being improved in the content of 7-amino-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (2) or an alkali metal salt thereof, the process being characterized in that an aqueous solution of an alkali metal salt of 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) is treated with a high porous polymer and/or active carbon as added thereto.