16639-23-9Relevant academic research and scientific papers
Synthesis of 3,4,5,6-Tetrahydro-2H-1,3,4-oxadiazin-2-ones Employing a Metal Hydride and Diethyl Carbonate: An Alternative Cyclization Method over 1,1′-Carbonyldiimidazole
Casper, David M.,Kieser, David,Blackburn, Jennifer R.,Hitchcock, Shawn R.
, p. 835 - 843 (2004)
A series of 3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-ones have been synthesized from valine, leucine, ephedrine, and norephedrine. The synthesis is accomplished through a process of nitrosation, reduction, and cyclization. The cyclization protocol employed involves the use of a metal hydride (LiH or NaH) and diethyl carbonate rather than 1,1′-carbonyldiimidazole.
