1664-58-0Relevant academic research and scientific papers
Heck arylation of conjugated alkenes with aryl bromides or chlorides catalyzed by immobilization of palladium in MCM-41
Yao, Fang,Liu, Jiaqin,Cai, Mingzhong
, p. 681 - 686 (2013)
A new 3-(2-aminoethylamino)propyl-functionalized MCM-41-immobilized palladium(II) complex [MCM-41-2N-PdCl2] was conveniently synthesized from commercially available and cheap 3-(2-aminoethylamino) propyltrimethoxysilane via immobilization on MCM-41, followed by reacting with palladium chloride. It was found that this heterogeneous palladium complex is a highly efficient catalyst for Heck arylation of conjugated alkenes with aryl bromides or chlorides using tetrabutylammonium bromide as additive and can be reused for at least six consecutive trials without any decreases in activity.
Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor
El-Haggar, Radwan,Kamikawa, Ken,Machi, Kazuya,Ye, Zhengmao,Ishino, Yuko,Tsumuraya, Takeshi,Fujii, Ikuo
supporting information; experimental part, p. 1169 - 1172 (2010/06/15)
Based on structural information for a peptide (P8-2KAQ) that binds to granulocyte-colony stimulating factor receptor (G-CSFR), small ligands with a biaryl scaffold were designed and their binding affinities were evaluated.
