1664-62-6

Basic information

• Product Name: 3-(2-Aminophenyl)propenoic acid methyl ester
• Synonyms: 3-(2-Aminophenyl)propenoic acid methyl ester;METHYL 3-(2-AMINOPHENYL)ACRYLATE;3-(2-Aminophenyl)-2-propenoic acid methyl ester;Methyl 2-aminocinnamate;Methyl o-aminocinnamate
• CAS NO: 1664-62-6
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.2
• Mol File: 1664-62-6.mol
• Article Data: 25

Chemical Properties

• Melting Point: 67℃
• Boiling Point: 317.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.160±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• PKA: 1.35±0.10(Predicted)
• CAS DataBase Reference: 3-(2-Aminophenyl)propenoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Aminophenyl)propenoic acid methyl ester(1664-62-6)
• EPA Substance Registry System: 3-(2-Aminophenyl)propenoic acid methyl ester(1664-62-6)

Safety Data

• Hazardous Substances Data: 1664-62-6(Hazardous Substances Data)

Usage

General Description

3-(2-Aminophenyl)propenoic acid methyl ester, also known as 2-Amino-3-phenylacrylic acid methyl ester, is a chemical compound with the molecular formula C10H11NO2. It is a methyl ester derivative of 2-Aminocinnamic acid and is commonly used in the synthesis of various pharmaceuticals and organic compounds. This chemical is a white to off-white crystalline powder with a melting point of around 82-85°C. It is mainly utilized in the pharmaceutical industry for the production of drugs and in research laboratories for various synthetic processes. Additionally, it is also used in the development of agrochemicals, dyes, and other specialty chemicals.

Upstream product

• 39228-29-0 methyl 2-nitrocinnamate 
• 552-89-6 2-nitro-benzaldehyde 
• 615-43-0 2-iodophenylamine 
• 292638-85-8 acrylic acid methyl ester 
• 529-23-7 o-aminobenzaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 612-41-9 2-nitrocinnamic acid 
• 615-36-1 2-bromoaniline 

Downstream Products

• 639478-88-9 3-(2-(nitroacetylamino)phenyl)propenonic acid methyl ester 
• 1040112-72-8 C₁₅H₁₉NO₄ 
• 1206797-34-3 C₁₀H₉N₃O₂ 
• 1440969-37-8 C₂₁H₂₃NO₄S 
• 1440969-63-0 C₂₁H₂₁NO₃S 
• 945862-20-4 C₁₇H₁₇NO₄S 
• 37118-72-2 4-(p-methoxyphenyl)-2-(1H)-quinolinone 
• 106015-76-3 4-(p-tolyl)-2-(1H)-quinolinone 
• 93501-08-7 4-(4-chlorophenyl)-2-quinolinone 
• 65848-66-0 4-(3-methoxyphenyl)-1H-quinolin-2-one 
• 144003-52-1 4-(o-methoxyphenyl)-2-(1H)-quinolinone 
• 1202-04-6 indole-2-carboxylic acid methyl ester 
• 275361-75-6 methyl 3-(2-formylaminophenyl)propenoate 

Relevant articles and documents

Preparation method of 3-(2-aminophenyl)-2-acrylate

The present invention relates to the field of pharmaceutical preparation technology, in particular a 3-(2-aminophenyl)-2-acrylate preparation method, comprising the following steps: 1) under the action of a base, o-nitrobenzaldehyde and malonate derivativ

One-Pot, Three-Step Synthesis of Benzoxazinones via Use of the Bpin Group as a Masked Nucleophile

The utilization of the Bpin group as a pronucleophile to facilitate the assembly of cyclic carbamates has been achieved. This one-pot process involves an initial copper-catalyzed borylation, a subsequent C-B bond oxidation to generate the reactive alcohol

Photoredox Catalysis toward 2-Sulfenylindole Synthesis through a Radical Cascade Process

A radical cascade process initiated through visible-light induced thiyl radical coupling with ortho-substituted arylisocianides followed by an intramolecular cyclization and subsequent aromatization to access 2-sulfenylindoles is described. The key thiyl radicals are promptly generated via a hydrogen atom transfer event. The redox-neutral protocol features broad substrate scope, excellent functional group tolerance, and mild reaction conditions. Furthermore, the implementation of a continuous flow variant allows smooth scalability with a short residence time through process intensification.