166402-53-5Relevant academic research and scientific papers
Quinoxaline chemistry. Part 4. 2-(R)-anilinoquinoxalines as nonclassical antifolate agents. Synthesis, structure elucidation and evaluation of in vitro anticancer activity
Loriga,Fiore,Sanna,Paglietti
, p. 289 - 301 (2007/10/02)
Thirty-five quinoxalines bearing a substituted amiline group on position 2 and various substituents on positions 3, 6, 7 and 8 were prepared in order to evaluate in vitro anticancer activity. Structural elucidation of some isomeric quinoxalinones formed by ring closure of 4-substituted-1,2-diaminobenzenes with dicarbonyl compounds was achieved by comparison with one isomer coming from an unambiguous independent route. Preliminary in vitro screening at NCI showed that many compounds exhibited a moderate to strong growth inhibition activity on various cell lines between 10-5 and 10-4 molar concentrations.
