166403-66-3 Usage
General Description
Tenofovir disoproxil fumarate (TDF) is a prodrug of tenofovir diphosphate, a nucleotide reverse transcriptase inhibitor (NtRTI) that is used in the treatment of HIV and chronic hepatitis B. Tenofovir diphosphate is an active metabolite that inhibits the activity of the HIV-1 reverse transcriptase enzyme, ultimately blocking the replication of the virus. It is also known to have a high barrier to resistance and a long half-life, making it a potent and effective antiviral agent. Tenofovir diphosphate is typically administered in combination with other antiretroviral drugs as part of a comprehensive treatment regimen for HIV infection.
Check Digit Verification of cas no
The CAS Registry Mumber 166403-66-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,6,4,0 and 3 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 166403-66:
(8*1)+(7*6)+(6*6)+(5*4)+(4*0)+(3*3)+(2*6)+(1*6)=133
133 % 10 = 3
So 166403-66-3 is a valid CAS Registry Number.
166403-66-3Relevant articles and documents
Nucleoside diphosphate kinase and the activation of antiviral phosphonate analogs of nucleotides: Binding mode and phosphorylation of tenofovir derivatives
Koch, Kerstin,Chen, Yuxing,Feng, Joy Y.,Borroto-Esoda, Katyna,Deville-Bonne, Dominique,Janin, Joel,Morera, Solange
body text, p. 776 - 792 (2010/09/03)
Tenofovir is an acyclic phosphonate analog of deoxyadenylate used in AIDS and hepatitis B therapy. We find that tenofovir diphosphate, its active form, can be produced by human nucleoside diphosphate kinase (NDPK), but with low efficiency, and that creati
