16641-51-3

Basic information

• Product Name: (4aS)-4aα,5,6,7,8,8a,9,9aα-Octahydro-3,8aβ-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
• Synonyms: (4aS)-4aα,5,6,7,8,8a,9,9aα-Octahydro-3,8aβ-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one;8-Epiasterolide
• CAS NO: 16641-51-3
• Molecular Formula: C₁₅H₂₀O₂
• Molecular Weight: 232.3181
• Mol File: 16641-51-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4aS)-4aα,5,6,7,8,8a,9,9aα-Octahydro-3,8aβ-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4aS)-4aα,5,6,7,8,8a,9,9aα-Octahydro-3,8aβ-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one(16641-51-3)
• EPA Substance Registry System: (4aS)-4aα,5,6,7,8,8a,9,9aα-Octahydro-3,8aβ-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one(16641-51-3)

Safety Data

• Hazardous Substances Data: 16641-51-3(Hazardous Substances Data)

Upstream product

• 74064-03-2 (3aR,4aS,8aR,9aS)-3,8a-Dimethyl-5-methylene-3-phenylsulfanyl-decahydro-naphtho[2,3-b]furan-2-one 
• 3484-43-3 (+/-)-atractylon 
• 487-51-4 4-carbethoxy-3-methyl-2-cyclohexen-1-one 
• 74842-02-7 (±)-ethyl (1R,2S)-2-methyl-4-oxo-2-vinylcyclohexane-1-carboxylate 
• 74842-03-8 (±)-ethyl (7S,8R)-7-methyl-7-vinyl-1,4-dioxaspiro[4.5]decane-8-carboxylate 
• 18664-32-9 1,3-dimethoxypropan-2-one 
• 3241-65-4 (+/-)-8a-methyl-5-methylene-octahydro-naphthalen-2(1H)-one 
• 105631-43-4 (4'aS,8'aR)-8'a-Methyl-5'-methylene-octahydro-spiro[[1,3]dioxolane-2,2'-naphthalene] 
• 600151-49-3 6-methoxy-4a-methyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-1-one 
• 162657-45-6 6-methoxy-4a-methyl-1-(trimethylsilyloxy)-2,3,4,4a,5,8-hexahydronaphthalene 
• 1201-61-2 1,2,3,4,5,8-hexahydro-1-hydroxy-6-methoxynaphthalene 
• 2844-80-6 1,2,3,4,5,8-hexahydro-1-oxo-6-methoxynaphthalene 

Downstream Products

• 182426-37-5 (+/-)-3,8a,3',8'a-tetramethyl-5,5'-dimethylene-4,4a,5,6,7,8,8a,9,4',4'a,5',6',7',8',8'a,9'-hexadecahydro-[9a,9'a]bi[naphtho[2,3-b]furanyl]-2,2'-dione 
• 6466-81-5 3,8a-dimethyl-5-methylene-4a,5,6,7,8,8a-hexahydro-4H-naphtho[2,3-b]furan-2-one 
• 182426-37-5 3,8a,3',8'a-tetramethyl-5,5'-dimethylene-4,4a,5,6,7,8,8a,9,4',4'a,5',6',7',8',8'a,9'-hexadecahydro[9a,9'a]bi[naphtho[2,3-b]furanyl]-2,2'-dione 
• 182426-37-5 (+/-)-3,8a,3',8'a-tetramethyl-5,5'-dimethylene-4,4a,5,6,7,8,8a,9,4',4'a,5',6',7',8',8'a,9'-hexadecahydro-[9a,9'a]bi[naphtho[2,3-b]furanyl]-2,2'-dione 
• 182426-37-5 (+/-)-3,8a,3',8'a-tetramethyl-5,5'-dimethylene-4,4a,5,6,7,8,8a,9,4',4'a,5',6',7',8',8'a,9'-hexadecahydro-[9a,9'a]bi[naphtho[2,3-b]furanyl]-2,2'-dione 
• 94204-13-4 9a-hydroxy-3,8a-dimethyl-5-methylene-4a,5,6,7,8,8a,9,9a-octahydro-4H-naphtho[2,3-b]furan-2-one 
• 182426-37-5 3,8a,3',8'a-tetramethyl-5,5'-dimethylene-4,4a,5,6,7,8,8a,9,4',4'a,5',6',7',8',8'a,9'-hexadecahydro-[9a,9'a]bi[naphtho[2,3-b]furanyl]-2,2'-dione 
• 3484-43-3 (+/-)-atractylon 

Relevant articles and documents

A general, concise, 'collective' approach to eudesmanolide sesquiterpenoids: Total synthesis of bioactive atractylenolides I-IV and related natural products

Total synthesis of seven bioactive atractylenolide-type eudesmanolides from Hagemann's ester, following, a short, scalable, adaptable, and diversity oriented protocol, has been accomplished. This effort opens a gateway to access through synthesis an exceptionally potent and promising group of natural products and their congeners of contemporary interest.

Biomimetic synthesis of biatractylolide and biepiasterolide

(Matrix presented) The biomimetic synthesis of the bisesquiterpenoids biatractylolide 1 and biepiasterolide 2 is reported.

Structure and autoxidation of atractylon.

-