166438-65-9 Usage
Description
1-(4-Methanesulfonyl-phenyl)-piperidin-4-ol, commonly known as Suvorexant, is a pharmaceutical compound that functions as an orexin receptor antagonist. It is specifically designed to treat insomnia by inhibiting the activity of orexin, a neurotransmitter that promotes wakefulness and alertness. As a central nervous system depressant, Suvorexant is intended for short-term use to address difficulties in falling asleep or maintaining sleep. It is administered orally in tablet form and is subject to potential side effects such as daytime drowsiness, headaches, and dizziness, which underscores the importance of following medical guidance for its use.
Uses
Used in Pharmaceutical Industry:
1-(4-Methanesulfonyl-phenyl)-piperidin-4-ol is used as a medication for the treatment of insomnia. It serves as an orexin receptor antagonist, targeting the neurotransmitter orexin to reduce wakefulness and promote sleep onset and maintenance in individuals experiencing sleep disturbances.
Used in Sleep Aid Applications:
Suvorexant is utilized as a sleep aid for individuals who have trouble falling asleep or staying asleep. Its mechanism of action involves blocking orexin receptors, which helps to suppress the arousal signals that keep individuals awake, thereby facilitating a more restful sleep.
It is crucial to note that Suvorexant should be used under the supervision of a healthcare professional to ensure proper dosage and to minimize the risk of side effects and potential drug interactions.
Check Digit Verification of cas no
The CAS Registry Mumber 166438-65-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,6,4,3 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 166438-65:
(8*1)+(7*6)+(6*6)+(5*4)+(4*3)+(3*8)+(2*6)+(1*5)=159
159 % 10 = 9
So 166438-65-9 is a valid CAS Registry Number.
166438-65-9Relevant articles and documents
Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive
Han, Dongyang,Li, Sasa,Xia, Siqi,Su, Mincong,Jin, Jian
supporting information, p. 12349 - 12354 (2020/09/09)
An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodology features a simple NiII salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides were coupled successfully with primary and secondary alkyl amines, and anilines in good to excellent yields. Similarly, benzophenone imine gave the corresponding N-arylation product in an excellent yield.
