16650-76-3

Usage

Uses

Used in Pharmaceutical Industry:
1-Methyl-d3-imidazole is used as a bone resorption inhibitor for the treatment of conditions associated with excessive bone loss. Its ability to inhibit bone resorption makes it a potential therapeutic agent in managing osteoporosis and other bone-related disorders.
Used in Chemical Research:
As a deuterated compound, 1-Methyl-d3-imidazole is utilized in chemical research and analysis. The presence of deuterium (d3) in its structure allows for enhanced detection and tracing of the compound in various chemical reactions and processes, making it a valuable tool for studying reaction mechanisms and improving synthetic methodologies.
Used in Material Science:
The unique chemical properties of 1-Methyl-d3-imidazole also make it suitable for applications in material science. Its potential use in the development of new materials with specific properties, such as improved stability or reactivity, can contribute to advancements in various industries, including pharmaceuticals, agriculture, and environmental management.

InChI:InChI=1/C4H6N2/c1-6-3-2-5-4-6/h2-4H,1H3/i1D3

Upstream product

• 288-32-4 1H-imidazole 
• 811-98-3 d⁽⁴⁾-methanol 
• 865-50-9 iodomethane-d3 

Downstream Products

• 285978-27-0 1-methylimidazole-d₆ 

Relevant academic research and scientific papers

Transition-metal free ring deuteration of imidazolium ionic liquid cations

A simple, low-cost and transition-metal free ring deuteration procedure applicable to ionic liquids (ILs) with imidazolium cations has been developed. Reaction profiles for the exchange have been measured.

Characterization of nonderivatized plant cell walls using high-resolution solution-state NMR spectroscopy

A recently described plant cell wall dissolution system has been modified to use perdeuterated solvents to allow direct in-NMR-tube dissolution and high-resolution solution-state NMR of the whole cell wall without derivatization. Finely ground cell wall material dissolves in a solvent system containing dimethylsulfoxide-d6 and 1-methylimidazole-d6 in a ratio of 4:1 (v/v), keeping wood component structures mainly intact in their near-native state. Two-dimensional NMR experiments, using gradient-HSQC (heteronuclear single quantum coherence) 1 -bond 13C-1H correlation spectroscopy, on nonderivatized cell wall material from a representative gymnosperm Pinus taeda (loblolly pine), an angiosperm Populus tremuloides (quaking aspen), and a herbaceous plant Hibiscus cannabinus (kenaf) demonstrate the efficacy of the system. We describe a method to synthesize 1-methylimidazole-d6 with a high degree of perdeuteration, thus allowing cell wall dissolution and NMR characterization of nonderivatized plant cell wall structures. Copyright

Transition-metal-free synthesis of perdeuterated imidazolium ionic liquids by alkylation and H/D exchange

Economic, transition-metal-free syntheses of partially or completely deuterated imidazolium ionic liquids (ILs) were developed. Double alkylation starting from imidazole afforded side-chain deuterated imidazolium ionic liquids, which subsequently were ful

A highly efficient synthetic procedure for deuteriating imidazoles and imidazolium salts

Both substituted imidazoles and 1,3-dialkylimidazolium salts can be fully deuteriated on the heterocyclic ring using D2O over heterogeneous Pd catalysts: deuteriated 1-alkyl-3-methylimidazolium chloride and hexafluorophosphate ionic liquids can also be prepared in good yields utilising readily available and relatively low cost sources of deuterium.

Synthesis of sequentially deuterated 1-n-Butyl-3-methylimidazolium ionic liquids

Deuterium isotopologues of the ionic liquid (IL) 1-n-butyl-3- methylimidazolium chloride ([C4mim]Cl) sequentially labeled on the C-1″, C-1′, C-2′, C-3′, and C-4′ positions of the N-alkyl groups were prepared following a strategy that minimizes

Molecular and Lattice Motions for the Transformation of trans-L2Mo(CO)4 to cis-L2Mo(CO)4 in a Single Crystal

Single crystals of trans-L2Mo(CO)4 (L = 1,3-dimethyl-4-imidazolin-2-ylidene) transform to crystals of cis-L2Mo(CO)4 upon heating to 133 deg C.X-ray analyses demonstrate that the lattice transformation accompanying the molecular isomerization process is of the martensitic type.Morphological studies reveal that phase boundaries move parallel to close packed planes.The interrelation between lattice movements and intramolecular reorientations is analyzed. - Keywords: Octahedral trans-cis-Isomerization, Single Crystal Reactions