166527-08-8

Upstream product

• 953039-28-6 2-amino-5-bromo-3-chlorobenzoic acid hydrobromide 
• 58026-21-4 2-amino-5-bromo-3-chloro-benzoic acid 
• 6388-47-2 2-amino-3-chlorobenzoic acid 

Downstream Products

• 1425504-22-8 (R)-tert-butyl 1-(4-(8-chloro-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethylcarbamate 
• 1425504-28-4 C₂₃H₂₀ClN₅O 
• 1036755-78-8 6-bromo-8-chloroquinazolin-2-ol 

Relevant academic research and scientific papers

NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES, KIDNEY DISEASE AND DIABETES

The present invention relates to Compounds of Formula I: I and pharmaceutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Fo

KAPPA OPIOID RECEPTOR ANTAGONISTS AND PRODUCTS AND METHODS RELATED THERETO

Compounds are provided that antagonize the kappa-opioid receptor (KOR) and products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof: (I) wherein X, Y, R1, R2, R4, R5 R6, R7, R8 and R11 are as defined herein.

INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR

Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

QUINAZOLINES FOR PDK1 INHIBITION

The invention provides novel quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.