1665292-86-3Relevant articles and documents
Super-secondary structure peptidomimetics: Design and synthesis of an α-α hairpin analogue
Nevola, Laura,Rodriguez, Johanna M.,Thompson, Sam,Hamilton, Andrew D.
, p. 586 - 590 (2013)
The α-α helix motif presents key recognition domains in protein-protein and protein-oligonucleotide binding, and is one of the most common super-secondary structures. Herein, we describe the design, synthesis and structural characterisation of an α-α hairpin analogue based on a tetra-coordinated Pd(II) bis-(iminoisoquinoline) complex as a template for the display of two α-helix mimics. This approach is exemplified by the attachment of two biphenyl peptidomimetics to reproduce the side chains of the i and i+4 residues of two helices. 2013
