16664-48-5

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 4440-01-1 lithium phenylacetylide 
• 69936-53-4 6-phenylhex-5-yn-1-ol 
• 536-74-3 phenylacetylene 

Downstream Products

• 16664-52-1 hex-5-en-1-yn-1-ylbenzene 
• 4410-77-9 benzylidenecyclopentane 
• 15507-35-4 1-benzylcyclopentene 
• 1129-65-3 (hex-1-yn-1-yl)benzene 
• 771-98-2 1-Phenylcyclohexene 
• 6111-82-6 1-phenylhex-1-ene 
• 1254985-02-8 N-(2,2-diethoxyethyl)-4-methyl-N-(6-phenylhex-5-ynyl)-benzenesulfonamide 
• 1300041-06-8 C₂₃H₂₄ 
• 1300040-90-7 C₂₃H₂₄ 
• 1300041-02-4 8-phenyl-1,2,3,4,9,10,11,12-octahydrocyclohepta[de]fluorene 
• 16664-50-9 1-phenyl-1-decyne 

Relevant academic research and scientific papers

Rhodium-catalyzed intramolecular cascade sequence for the formation of fused carbazole-annulated medium-sized rings by cleavage of C(sp2)-H/C(sp3)-H bonds

The rhodium(iii)-catalyzed intramolecular annulation of alkyne-tethered 3-(indol-3-yl)-3-oxopropanenitriles for the synthesis of fused carbazole scaffolds via C-H activation has been developed. A series of six-, seven-, and eight-membered hydroazepino[3,2

Metal-Free Synthesis of Highly Substituted Pyridines by Formal [2+2+2] Cycloaddition under Mild Conditions

The synthesis of pyridines through direct intermolecular cycloaddition of alkynes and nitriles is a contemporary challenge in organic synthesis. A Br?nsted acid mediated formal [2+2+2] cycloaddition of heteroalkynes and nitriles was developed that proceed

Ni-Catalyzed Divergent Cyclization/Carboxylation of Unactivated Primary and Secondary Alkyl Halides with CO2

A user-friendly Ni-catalyzed reductive cyclization/carboxylation of unactivated alkyl halides with CO2 is described. The protocol operates under mild conditions with an excellent chemoselectivity profile and a divergent syn/anti selectivity pat

An unprecedented tandem annulation of ω-azido-1-alkynes with diaryl-iodonium salts: A facile synthesis of polycyclic quinolines

Polysubstituted quinolines are synthesized through an unprecedented cascade annulation of ω-azido-1-alkynes with diaryliodonium salts, which serve as C2-building blocks. The reaction proceeds smoothly and is catalyzed by Cu(I) catalysts to give various qu

A concise construction of polycyclic quinolines via annulation of ω-cyano-1-alkynes with diaryliodonium salts

A concise construction of polycyclic quinolines via intramolecular [2 + 2 + 2] annulation of ω-cyano-1-alkynes with diaryliodonium salts was realized. The process produced polycyclic quinolines in high yields with readily available staring materials and was tolerated with halogen substituents.

Kumada-Corriu reactions of alkyl halides with alkynyl nucleophiles

Pd2(dba)3-Ph3P-catalyzed Kumada-Corriu coupling reactions of unactivated alkyl bromides or iodides with an alkynyl nucleophile furnish Csp-Csp3 bond formation. Alkynyl nucleophiles can be alkynyllithiums or the corresponding Grignard reagents. The superior performance of Ph3P ligand over the trialkylphosphine ligands indicates that this cross-coupling reaction may be a reductive-elimination-controlled process.

Cyclizations of ω-Alkynyl Halides by Cr(II) Reduction

Reduction of halides of the types RCC(CH2)nX with Cr(II) in aqueous DMF containing ethylenediamine proceeds by way of the intermediate radicals which cyclize regioselectively in the n=4 and n=5 cases to give substituted methylenecycloalkanes.Experimental conditions which favor longer lifetimes for the intermediate radicals (low concentrations, slow addition times, and an inverse-addition mode) result in increased cyclization.The iodides curiously give more cyclic product than the corresponding bromides.These results are discussed.