166751-40-2Relevant academic research and scientific papers
Pyrimidine compounds and their use as modulators of chemokine receptor activity
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, (2008/06/13)
The invention provides certain heterocyclic compounds, processes, and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy; in formula (I), A is a group of formula (a) or (b).
Pyrimidine-thioalkyl and alkylether compounds
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Page 10, (2010/11/29)
The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I and pyrimidine-thioalkyl and alkylethers of Formula IA, namely the compounds of Formula I whereR4 is selected from the group consisting of -H or -NRsub
Pyrimidine thioethers: A novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV
Nugent, Richard A.,Schlachter, Stephen T.,Murphy, Michael J.,Cleek, Gary J.,Poel, Toni J.,Wishka, Donn G.,Graber, David R.,Yagi, Yoshihiko,Keiser, Barbara J.,Olmsted, Robert A.,Kopta, Laurie A.,Swaney, Steven M.,Poppe, Susan M.,Morris, Joel,Tarpley, W. Gary,Thomas, Richard C.
, p. 3793 - 3803 (2007/10/03)
A series of pyrimidine thioethers was synthesized and evaluated for inhibitory properties against wild-type HIV-1 reverse transcriptase (RT) and an RT carrying the resistance-conferring mutation P236L. Modifications of both the pyrimidine and the function
