166751-41-3Relevant academic research and scientific papers
Pyrimidine thioethers: A novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV
Nugent, Richard A.,Schlachter, Stephen T.,Murphy, Michael J.,Cleek, Gary J.,Poel, Toni J.,Wishka, Donn G.,Graber, David R.,Yagi, Yoshihiko,Keiser, Barbara J.,Olmsted, Robert A.,Kopta, Laurie A.,Swaney, Steven M.,Poppe, Susan M.,Morris, Joel,Tarpley, W. Gary,Thomas, Richard C.
, p. 3793 - 3803 (1998)
A series of pyrimidine thioethers was synthesized and evaluated for inhibitory properties against wild-type HIV-1 reverse transcriptase (RT) and an RT carrying the resistance-conferring mutation P236L. Modifications of both the pyrimidine and the function
Pyrimidine-thioalkyl and alkylether compounds
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Page 10, (2010/11/29)
The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I and pyrimidine-thioalkyl and alkylethers of Formula IA, namely the compounds of Formula I whereR4 is selected from the group consisting of -H or -NRsub
