166758-08-3

Upstream product

• 166758-07-2 4-N-benzoyl-2'-deoxy-3'-O-tert-butyldiphenylsilyl-5'-O-dimethoxytritylcytidine 
• 60920-99-2 N⁴-Benzoyl-5'-O-monomethoxytrityl-2'-deoxycytidine 
• 67219-55-0 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 

Downstream Products

• 166758-09-4 N⁴-Benzoyl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxy-5'-O-phthalimidocytidine 
• 198267-38-8 N⁴-benzoyl-1-<3-O-tert-butyldiphenylsilyl-5-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl>cytosine 
• 198267-39-9 N⁴-benzoyl-1-<5-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl>cytosine 
• 166758-10-7 5'-O-Amino-N⁴-benzoyl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxycytidine 
• 166758-11-8 5'-O-Amino-N⁴-benzoyl-2'-deoxycytidine 

Relevant academic research and scientific papers

NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS

The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.

Disaccharide nucleosides: Synthesis of pyrimidine 5′-O-β-D-ribofuranosylribo- and -2′-deoxyribonucleosides

The easy synthesis of pyrimidine 5′-O-β-D-ribofuranosyl nucleosides from 2′,3′-di-O-acetylribonucleosides and 3′-O-tert-butyldiphenylsilyl-2′-deoxyribonucleosides is described. The stability upon O-glycosylation of various protecting groups is studied. Th

Synthesis of 5'-O-amino-2'-deoxypyrimidine and purine nucleosides: Building-blocks for antisense oligonucleosides

An efficient synthesis of 5'-O-amino-2'-deoxy analogs of uridine 1, thymidine 2, cytidine 3, 5-methylcyitidine 3a, adenosine 4, and guanosine 5 was accomplished. The key step of 5'-O-N-bond formation in 2'-deoxynucleosides 1-5 was achieved via a Mitsunobu reaction in excellent yields. The 5'-O-amino nucleosides 1-5 are useful building-blocks for the synthesis of nucleoside dimers linked by a methylene(methylimino) (MMI) bridge. MMI is a novel phosphate surrogate for antisense oligonucleosides.