166760-67-4Relevant academic research and scientific papers
Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core
Frédérick, Rapha?l,Dumont, Willy,Ooms, Frédéric,Aschenbach, Lindsey,Van Der Schyf, Cornelis J.,Castagnoli, Neal,Wouters, Johan,Krief, Alain
, p. 3743 - 3747 (2006)
The synthesis and enzyme inhibitor properties of reversible type B monoamine oxidase inhibitors are described. These compounds belong to the 5H-indeno[1,2-c]pyridazine family and possess a hydrophobic benzyloxy or 4,4,4-trifluorobutoxy side chain which, i
Inhibition of monoamine oxidase-b by 5H-indeno[1,2-c]pyridazines: Biological activities, quantitative structure-activity relationships (QSARs) and 3D-QSARs
Kneubuhler,Thull,Altomare,Carta,Gaillard,Carrupt -,Carotti,Testa
, p. 3874 - 3883 (2007/10/03)
A large series (66 compounds) of indeno[1,2-c]pyridazin-5-ones (IPs) were synthesized and tested on their monoamine oxidase-A (MAO-A) and MAO-B inhibitory activity. All of the tested compounds acted preferentially on MAO- B displaying weak (nonmeasurable
