1668-13-9

Basic information

• Product Name: H-ALA-PNA
• Synonyms: ALA-PNA;ALANINE-PNA;L-ALANINE 4-NITROANILIDE;L-ALANINE P-NITROANILIDE;H-ALA-PNA;alanine-4-nitroanilide;(2S)-N-(4-Nitrophenyl)-2-aminopropionamide;(S)-2-Amino-N-(4-nitrophenyl)propanamide
• CAS NO: 1668-13-9
• Molecular Formula: C₉H₁₁N₃O₃
• Molecular Weight: 209.2
• Mol File: 1668-13-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 95 °C
• Boiling Point: 443.4°Cat760mmHg
• Flash Point: 221.9°C
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 4.67E-08mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: -15°C
• PKA: 12.92±0.70(Predicted)
• CAS DataBase Reference: H-ALA-PNA(CAS DataBase Reference)
• NIST Chemistry Reference: H-ALA-PNA(1668-13-9)
• EPA Substance Registry System: H-ALA-PNA(1668-13-9)

Safety Data

• Hazardous Substances Data: 1668-13-9(Hazardous Substances Data)

Usage

Chemical Properties

Yellow powder

InChI:InChI=1/C9H11N3O3/c1-6(10)9(13)11-7-2-4-8(5-3-7)12(14)15/h2-6H,10H2,1H3,(H,11,13)/t6-/m0/s1

Upstream product

• 52299-14-6 N-succinyl-L-alanyl-L-alanyl-L-alanine 4-nitroanilide 
• 1168-86-1 benzyl (S)-(1-((4-nitrophenyl)amino)-1-oxopropan-2-yl)carbamate 
• 52815-81-3 t-butoxycarbonyl-L-alanine p-nitroanilide 

Downstream Products

• 111196-00-0 ((S)-3-Methyl-1-{(S)-3-methyl-1-[(S)-1-(4-nitro-phenylcarbamoyl)-ethylcarbamoyl]-butylcarbamoyl}-butyl)-carbamic acid benzyl ester 
• 111196-01-1 benzyloxycarbonylglycyl-prolyl-alanine p-nitroanilide 
• 60354-61-2 L-Ala-L-Ala-L-Ala-pNA 
• 52299-14-6 N-succinyl-L-alanyl-L-alanyl-L-alanine 4-nitroanilide 
• 95574-42-8 (S)-1-(2-Amino-acetyl)-pyrrolidine-2-carboxylic acid [(S)-1-(4-nitro-phenylcarbamoyl)-ethyl]-amide 
• 142956-19-2 (S)-2-Amino-4-methyl-pentanoic acid {(S)-1-[(S)-1-(4-nitro-phenylcarbamoyl)-ethylcarbamoyl]-ethyl}-amide 
• 111196-06-6 3-carboxypropionylglycyl-glycyl-alanine p-nitroanilide 
• 85589-14-6 3-carboxypropionylalanyl-leucyl-alanine p-nitroanilide 
• 85589-13-5 3-carboxypropionylleucyl-alanyl-alanine p-nitroanilide 
• 111196-08-8 3-carboxypropionylglycyl-prolyl-alanine p-nitroanilide 
• 109835-08-7 Glp-Phe-Ala-pNA 
• 97986-02-2 ({(S)-1-[(S)-1-(4-Nitro-phenylcarbamoyl)-ethylcarbamoyl]-ethylcarbamoyl}-methyl)-carbamic acid benzyl ester 
• 176436-42-3 N-Boc-L-Phe-L-Ala-pNA 
• 85697-77-4 N-Boc-L-Leu-L-Ala-pNA 

Relevant articles and documents

Proline-based dipeptides with two amide units as organocatalyst for the asymmetric aldol reaction of cyclohexanone with aldehydes

A series of proline-based dipeptide organocatalysts with two amide units (1-16) have been developed and evaluated in the direct catalytic asymmetric aldol reactions of aldehydes with cyclohexanone. These catalysts showed good solubility in organic solvents compared with their corresponding carboxyl terminal dipeptides. The robust amide bond formation allowed structural modifications and fine tuning of catalyst properties by varying the stereo and electronic effects of the terminal amide to affect the ability of hydrogen bonding formation between the catalysts and the substrates. The reactions proceeded smoothly in high yields (up to 99%), enantioselectivities (up to 98% ee) and anti-diastereoselectivities (up to 99:1) in the presence of bifunctional organocatalyst 4 under the optimal reaction conditions.

Amino acids and peptides. XX. Inhibition of papain by succinyl-Gln-Val-Val-Ala-Ala-p-nitroanilide, a common sequence of endogenous thiol proteinase inhibitors.

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Synthesis of chromogenic substrates specific for human spleen fibrinolytic proteinase (SFP) and human leukocyte elastase (LE).

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