166806-40-2

Basic information

• Product Name: 2,6-Dimethyl-N3-[3-(4,4-diphenylpiperidin-1-yl)propyl]-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide
• Synonyms: SNAP-5150
• CAS NO: 166806-40-2
• Molecular Formula: C₃₅H₃₉N₅O₄
• Molecular Weight: 593.73218
• Mol File: 166806-40-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-Dimethyl-N3-[3-(4,4-diphenylpiperidin-1-yl)propyl]-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dimethyl-N3-[3-(4,4-diphenylpiperidin-1-yl)propyl]-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide(166806-40-2)
• EPA Substance Registry System: 2,6-Dimethyl-N3-[3-(4,4-diphenylpiperidin-1-yl)propyl]-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide(166806-40-2)

Safety Data

• Hazardous Substances Data: 166806-40-2(Hazardous Substances Data)

Upstream product

• 210829-68-8 5-Carbamoyl-2,6-dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 2-cyano-ethyl ester 
• 555-16-8 4-nitrobenzaldehdye 

Relevant articles and documents

Identification of a dihydropyridine as a potent α(1a) adrenoceptor- selective antagonist that inhibits phenylephrine-induced contraction of the human prostate

A number of novel dihydropyridine derivatives based upon 1,4-dihydro-3- (methoxycarbonyl)-2,6-dimethyl-4-(4-nitrophenyl)-5-((3-(4,4- dihyphenylpiperidin-1-yl)propyl)aminocarbonyl)pyridine (4) have been synthesized and tested at cloned human α adrenoceptors as well as the rat L- type calcium channel. Within this compound series, 5-(aminocarbonyl)-1,4- dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3-((3-(4,4-diphenylpiperidin-1- yl)propyl)aminocarbonyl)pyridine (19)displayed good binding affinity and selectivity for the α(1a) adrenoceptor (pK(i) = 8.73) and potently inhibited (pA2 = 9.23) phenylephrine-induced contraction of the human prostate.