166809-66-1Relevant academic research and scientific papers
Identification of a dihydropyridine as a potent α(1a) adrenoceptor- selective antagonist that inhibits phenylephrine-induced contraction of the human prostate
Wong, Wai C.,Chiu, George,Wetzel, John M.,Marzabadi, Mohammad R.,Nagarathnam, Dhanapalan,Wang, Diana,Fang, James,Miao, Shou Wu,Hong, Xingfang,Forray, Carlos,Vaysse, Pierre J.-J.,Branchek, Theresa A.,Gluchowski, Charles,Tang, Rui,Lepor, Herbert
, p. 2643 - 2650 (2007/10/03)
A number of novel dihydropyridine derivatives based upon 1,4-dihydro-3- (methoxycarbonyl)-2,6-dimethyl-4-(4-nitrophenyl)-5-((3-(4,4- dihyphenylpiperidin-1-yl)propyl)aminocarbonyl)pyridine (4) have been synthesized and tested at cloned human α adrenoceptors as well as the rat L- type calcium channel. Within this compound series, 5-(aminocarbonyl)-1,4- dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3-((3-(4,4-diphenylpiperidin-1- yl)propyl)aminocarbonyl)pyridine (19)displayed good binding affinity and selectivity for the α(1a) adrenoceptor (pK(i) = 8.73) and potently inhibited (pA2 = 9.23) phenylephrine-induced contraction of the human prostate.
