16681-69-9

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 27, p. 2021, 1990 DOI: 10.1002/jhet.5570270733

Upstream product

• 624-67-9 Propargylic aldehyde 
• 624-90-8 methyl azide 
• 133902-56-4 [1-(1-Methyl-1H-[1,2,3]triazol-4-yl)-meth-(E)-ylidene]-phenyl-amine 
• 77177-21-0 (1-methyl-1H-[1,2,3]triazol-4-yl)methanol 
• 151918-33-1 Methyl-[1-[1,2,3]thiadiazol-4-yl-meth-(E)-ylidene]-amine 
• 513-81-5 2,3-dimethyl-buta-1,3-diene 
• 129027-59-4 [1-(1-Methyl-1H-[1,2,3]triazol-4-yl)-meth-(E)-ylidene]-phenyl-amine 

Downstream Products

• 16681-71-3 1-methyl-1H-1,2,3-triazole-4-carboxylic acid 
• 114488-58-3 p-Methoxybenzyl (5R) 6-(1-methyl-1,2,3-triazol-4-ylmethylene)penem-3-carboxylate 
• 1207454-72-5 ethyl 2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,3-triazol-4-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate 

Relevant academic research and scientific papers

3-CARBOXYLIC ACID PYRROLES AS NRF2 REGULATORS

The present invention relates to 3-carboxylic acid pyrrole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators. In particular, the compounds of this invention include a compound of Formula (I)

N-ARYL PYRAZOLES AS NRF2 REGULATORS

The present invention relates to N-aryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators. In particular, the compounds of this invention include a compound of Formula (I).

ARYLCYCLOHEXYL PYRAZOLES AS NRF2 REGULATORS

The present invention relates to arylcyclohexyl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.

BIARYL PYRAZOLES AS NRF2 REGULATORS

The present invention relates to biaryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.

A polymorphism-dependent T1/2 shift of 100 K in a hysteretic spin-crossover complex related to differences in intermolecular weak CH?X hydrogen bonds (X = S vs. S and N)

A neutral mononuclear iron(ii) complex with a 1,2,3-triazole-containing tetradentate ligand has been obtained as two solvent-free polymorphs. Both polymorphs show hysteretic spin crossover with a polymorphism-dependent T1/2 shift of 100 K that

METHODS OF USING DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE)POLYMERASE (PARP)

Provided herein are methods of treating cancer comprising administering a topoisomerase inhibitor, temozolomide, or a platin in combination with a Compound of Formula (I) or Formula (II), where the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein.

DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

Thermal Rearrangement of 4-Iminomethyl-1,2,3-thiadiazoles

Imines derived from 1,2,3-thiadiazole-4-carbaldehyde 4 rearrange thermally into 1,2,3-triazole-4-thiocarbaldehydes 6 which were trapped with anthracene or 2,3-dimethylbutadiene.In two cases, 1,2,3-thiadiazole-4-thiocarbaldehyde 9 was intercepted as the Di

Molecular Rearrangements of 4-Iminomethyl-1,2,3-Triazoles. Replacement of 1-Aryl Substituents in 1H-1,2,3-Triazole-4-carbaldehydes

The two structural isomers, 4 and 5, of 1-substituted-4-iminomethyl-1,2,3-triazoles are interconvertible when heated in dimethyl sulfoxide at 80 deg C.The equilibrium position depends on the electronic properties of the R-substituent, favoring 5 for R = alkyl, benzyl and anisyl, and 4 for p-chlorophenyl and p-nitrophenyl.An interesting application is the synthesis of 1-alkyl-1,2,3-triazole-4-carbaldehydes from 1-phenyl-1,2,3-triazole-4-carbaldehyde by Scheme I.The hydrazones 4i, j and the oxime 4k do not rearrange due to an unfavorable Z-configuration around the C=N bond, whereas the acyloximino derivative 4m is converted into the nitrile 11.The structures of the products have been fully characterized by 13C nmr spectroscopy and the mechanistic details of the rearrangement are discussed.

Replacement of Aryl by Alkyl in 1-Substituted 1H-1,2,3-Triazole-4-carbaldehydes

1-Phenyl-1,2,3-triazole-4-carbaldehyde is readily transformed into 1-alkyl-1,2,3-triazole-4-carbaldehydes by thermal isomerization of the corresponding imines, followed by acid hydrolysis.