16681-78-0

Basic information

• Product Name: 2H-Tetrazole, 2-methyl-
• Synonyms: 2H-Tetrazole, 2-methyl-;2-Methyl-2H-tetrazole
• CAS NO: 16681-78-0
• Molecular Formula: C₂H₄N₄
• Molecular Weight: 84.08
• Mol File: 16681-78-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 171.3 °C at 760 mmHg
• Flash Point: 57.4 °C
• Appearance: /
• Density: 1.4 g/cm³
• Vapor Pressure: 1.41mmHg at 25°C
• Refractive Index: 1.664
• CAS DataBase Reference: 2H-Tetrazole, 2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Tetrazole, 2-methyl-(16681-78-0)
• EPA Substance Registry System: 2H-Tetrazole, 2-methyl-(16681-78-0)

Safety Data

• Hazardous Substances Data: 16681-78-0(Hazardous Substances Data)

Usage

Description

2H-Tetrazole, 2-methyl-, also known as 2-methyl-2H-tetrazole, is a chemical compound belonging to the tetrazole family, characterized by a five-membered ring with four nitrogen atoms and one carbon atom. With the molecular formula C2H4N4, this methyl derivative of 2H-tetrazole is utilized in various fields, including pharmaceuticals, agrochemicals, and energetic materials. It has been investigated for its potential in developing drugs for cardiovascular diseases, central nervous system disorders, and cancer treatment, as well as serving as a building block in the synthesis of various organic compounds for industrial and research applications.

Uses

Used in Pharmaceutical Industry:
2H-Tetrazole, 2-methylis used as a pharmaceutical intermediate for the development of drugs targeting cardiovascular diseases, central nervous system disorders, and cancer treatment. Its unique chemical structure and properties contribute to the design and synthesis of novel therapeutic agents with improved efficacy and safety profiles.
Used in Agrochemical Industry:
In the agrochemical sector, 2-methyl-2H-tetrazole serves as a key component in the formulation of various pesticides and herbicides. Its ability to form stable complexes with metal ions and its reactivity with organic compounds make it a valuable ingredient in the development of effective and environmentally friendly agrochemical products.
Used in Energetic Materials:
2H-Tetrazole, 2-methylis utilized in the production of energetic materials, such as explosives and propellants, due to its high energy content and stability. Its incorporation into these materials enhances their performance and safety characteristics, making them suitable for various applications in the defense and aerospace industries.
Used in Organic Synthesis:
As a building block in organic synthesis, 2-methyl-2H-tetrazole is employed in the synthesis of a wide range of organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its versatile reactivity and stability make it an attractive candidate for the development of new chemical entities with potential applications in various industries.

InChI:InChI=1/C2H4N4/c1-6-4-2-3-5-6/h2H,1H3

Upstream product

• 288-94-8 1H-tetrazole 
• 77-78-1 dimethyl sulfate 
• 288-94-8 2H-tetrazole 
• 13175-00-3 2-methyl-2H-1,2,3,4-tetrazole-5-carboxylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 1025840-65-6 [(S)-2-Methyl-1-(2-methyl-2H-tetrazole-5-carbonyl)-propyl]-carbamic acid benzyl ester 
• 107403-53-2 1-[2-(4-Bromo-phenyl)-2-oxo-ethyl]-3-methyl-3H-tetrazol-1-ium; bromide 
• 107403-52-1 3-Methyl-1-(2-oxo-2-phenyl-ethyl)-3H-tetrazol-1-ium; bromide 
• 107403-54-3 3-Methyl-1-[2-(4-nitro-phenyl)-2-oxo-ethyl]-3H-tetrazol-1-ium; bromide 

Relevant articles and documents

Synthesis and structure of 1-tert-butyl-3-R-tetrazolium salts

An effective method was developed for the synthesis of 1,3-disubstituted tetrazolium salts by the quaternization of 2-monosubstituted tetrazoles, including functionally substituted compounds, with tert-butanol in 72% perchloric acid. An X-ray diffraction

Coordination chemistry with 1-methyl-5: H -tetrazole: Cocrystallization, laser-ignition, lead-free primary explosives-one ligand, three goals

The synthesis and characterization of 1-methyl-5H-tetrazole (1, MTZ) from 1,5H-tetrazole and methyl iodide is achieved. This neutral ligand was evaluated for its use in energetic transition metal complexes. The formation of complexes is a valuable concept because of their easy synthesis and the large number of possible combinations: (i) metal, (ii) ligand, and (iii) anion. A series of 31 new complexes based on MTZ as the ligand was prepared in order to tune their optical properties and sensitivity values by using seven different metals (Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Zn2+, and Ag+) and six different anions (chloride, nitrate, perchlorate, cyanodinitromethanide, picrate, and styphnate). This variation allows tailoring of the energetic properties of the desired molecule toward e.g. suitable primary explosives or laser-ignitable materials. Obtained compounds were characterized by low temperature single crystal X-ray diffraction, IR spectroscopy, elemental analysis and thermal analysis (DTA, DSC and TGA). The sensitivities toward external stimuli (impact, friction and electrostatic discharge) were determined according to the Bundesamt für Materialforschung und -prüfung (BAM) standard methods. These complexes have been characterized in laser ignition experiments and as new primary explosives. UV-vis measurements of selected complexes were carried out to get a possible insight into the laser initiation mechanism. For the first time a large number of compounds with sensitivities ranging from insensitive to very sensitive were synthesized to give a wide range of new materials for different possible applications.

Antibacterial compounds with improved pharmacokinetic profiles

Antibacterial compounds with improved pharmacokinetic profiles having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis and treatment of bacterial infections using the compounds are disclosed.