166812-98-2

Upstream product

• 166812-97-1 3-Benzoyl-1-((2R,4S,5R)-4-benzyloxy-5-benzyloxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione 
• 166812-92-6 1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione 
• 134111-32-3 1-(2-Deoxy-4-thio-β-D-ribofuranosyl)uracil 
• 134938-97-9 benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro-pentofuranoside 
• 166813-01-0 1-(5-O-trityl-2-deoxy-4-thio-β-D-threo-pentofuranosyl)uracil 
• 219613-62-4 1-((4S,5R)-4-Benzyloxy-5-benzyloxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione 
• 134700-26-8 1-O-acetyl-2-deoxy-3,5-di-O-benzyl-4-thio-D-erythro-pentafuranose 

Relevant academic research and scientific papers

Synthesis and biological activity of sugar-fluorinated 2',3'-dideoxy-4'- thioribofuranosyl nucleosides

The efficient DAST fluorination of deoxy-4'-thiopyrimidine nucleosides is reported. The cytidine analogue 3b was marginally effective against HIV.

Unanticipated retention of configuration in the DAST fluorination of deoxy-4′-thiopyrimidine nucleosides with "up" hydroxyl groups

Fluorination of 1-(5-O-trityl-3-deoxy-4-thio-β-D-threo-pentofuranosyl)uracil (17) and 1-(5-O-trityl-2-deoxy-4-thio-β-D-threo- pentofuranosyl)uracil (20) with DAST proceeded with exclusive retention of configuration. The structures of the products were con