166816-12-2 Usage
General Description
1-(6,7-Dichloro-8-nitro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-ethanone is a chemical compound that belongs to the class of benzodioxins. It is characterized by the presence of two chlorine atoms, a nitro group, and a ketone functional group. 1-(6,7-DICHLORO-8-NITRO-2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-1-ETHANONE may have potential applications in the field of organic synthesis, pharmaceuticals, and agrochemicals due to its unique structural features. It is important to handle and store this chemical with care, as it may pose health and environmental hazards if not handled properly. Further research and testing may be necessary to fully understand the properties and potential uses of 1-(6,7-Dichloro-8-nitro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-ethanone.
Check Digit Verification of cas no
The CAS Registry Mumber 166816-12-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,6,8,1 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 166816-12:
(8*1)+(7*6)+(6*6)+(5*8)+(4*1)+(3*6)+(2*1)+(1*2)=152
152 % 10 = 2
So 166816-12-2 is a valid CAS Registry Number.
166816-12-2Relevant articles and documents
Process development of the synthetic route to sulamserod hydrochloride
Kowalczyk, Bruce A.,Robinson III, James,Gardner, John O.
, p. 116 - 121 (2013/09/07)
Sulamserod hydrochloride is a potent S-HT4 receptor antagonist and was a clinical candidate for the treatment of gastrointestinal disorders. Process development of the fairly long synthetic route (12 linear, 14 overall steps) was undertaken. Process improvements were highlighted by aromatic chlorination choices in making dichlorobenzodioxan 2 and acetylaminochloroketone 7, a transfer hydrogenation reducing a nitro group and simultaneous aromatic dechlorination without ketone reduction to give aminoketone 5, and use of the potential mutagenic iodosulfonamide 14 to make quaternary salt 11. The chemistry was scaled-up into pilot plant reactor vessels to produce multikilogram amounts of Sulamserod hydrochloride suitable for drug development.
