166830-00-8

Upstream product

• 65-71-4 thymin 
• 96789-04-7 1,2,3,4-tetra-O-benzoyl-D-xylopyranose 
• 116165-26-5 5-Methyl-1-trimethylsilanyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 222848-82-0 1-{3'-O-(chloroacetyl)-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine 
• 435282-14-7 1-{2'-O-(chloroacetyl)-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine 
• 222848-84-2 1-{3'-O-acetyl-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine 
• 222848-72-8 1-{4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine 

Relevant academic research and scientific papers

Pentopyranosyl oligonucleotide systems: Communication No. 12. The β-D-xylopyranosyl-(4′ → 2′)-oligonucleotide system

β-D-Xylopyranosyl-(4′ → 2′)-oligonucleotides containing adenine and thymine as nucleobases were synthesized as a part of a systematic study of the pairing properties of pentopyranosyl oligonucleotides. Contrary to earlier expectations based on qualitative

3'-Deoxy-3'-hydroxymethyl-aldopentopyranosyl nucleoside synthesis. Part I

A straightforward synthesis of 3'-deoxy-3'-hydroxymethyl-aldopentopyranosyl nucleosides is described starting from β-D-xylopyranosyl nucleosides. β-D-xylopyranosyl thymine 17a,b,c, and uracil 17d are converted into the 4'-benzoylated derivatives 18a,b and further into the 2',3'-enepyranosyl compounds 19b,c. A 3'-hydroxymethyl appendix has been introduced using a free-radical methodology to furnish 20a,b. Inversion of configuration of the 4'-position yielded the target nucleosides 22a,b. X-ray and 1H NMR conformation analysis prove the equatorial orientation of the base moiety in the target compounds.