1668558-06-2Relevant academic research and scientific papers
Enantioselective direct α-alkylation of cyclic ketones by means of photo-organocatalysis
Arceo, Elena,Bahamonde, Ana,Bergonzini, Giulia,Melchiorre, Paolo
, p. 2438 - 2442 (2014/05/20)
We report here the first asymmetric catalytic alkylation of unmodified ketones with alkyl halides. This metal-free approach, which requires light in order to proceed, provides a rare example of highly enantioselective photochemical catalytic processes. An easily available cinchona-based primary amine catalyst guides both the stereoselectivity-defining event and, through the transient formation of photon-absorbing chiral electron donor-acceptor complexes, the photo-activation of the substrates. This journal is the Partner Organisations 2014.
