1668565-74-9Relevant articles and documents
Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
Williams, David K.,Markwalder, Jay A.,Balog, Aaron J.,Chen, Bin,Chen, Libing,Donnell, Jennifer,Haque, Lauren,Hart, Amy C.,Mandal, Sunil K.,Nation, Andrew,Shan, Weifang,Vite, Gregory D.,Covello, Kelly,Hunt, John T.,Jure-Kunkel, Maria N.,Seitz, Steven P.
, p. 732 - 736 (2018/02/12)
A novel series of o-phenylenediamine-based inhibitors of indoleamine 2,3-dioxygenase (IDO) has been identified. IDO is a heme-containing enzyme, overexpressed in the tumor microenvironment of many cancers, which can contribute to the suppression of the host immune system. Synthetic modifications to a previously described diarylether series resulted in an additional degree of molecular diversity which was exploited to afford compounds that demonstrated significant potency in the HeLa human cervical cancer IDO1 assay..
