166904-81-0Relevant articles and documents
2H-Benzimidazoles (Isobenzimidazoles). Part 9. Synthesis and Reactions of 4,6-Dibromo-2H-benzimidazole-2-spirocyclohexane
Hazelton, Justine C.,Iddon, Brian,Redhouse, Alan D.,Suschitzky, Hans
, p. 5597 - 5608 (1995)
The title compound 1 was prepared by condensation of 3,5-dibromo-o-phenylenediamine 10 with cyclohexanone and oxidation of the resulting 4,6-dibromo-1,3-dihydro-2H-benzimidazole-2-spirocyclohexane 5 with manganase dioxide.With sodium 2,3-dichlorophenoxide
SYNTHESIS AND REACTIONS OF 2H-BENZIMIDAZOLE-2-SPIROCYCLOHEXANES : AN APPLICATION OF "UMPOLING"
Iddon, Brian
, p. 673 - 701 (2007/10/02)
The title compounds are available through condensation of an o-phenylenediamine with cyclohexanone followed by oxidation of the resulting product with manganese dioxide.In this article we review their oxidation, reduction, and rearrangement reactions along with their reactions with nitrogen, oxygen, sulphur, and other nucleophiles.As well as the parent compound the reactions of the 5-chloro-, 5,6-dichloro-, 4,6-dibromo-, 5-phenylsulphonyl- and 5-methoxy-derivative are discussed in some detail.Some applications of the methodology developed, particularly to the synthesis of actual or potential benzimidazole anthelminthics, are given also.