16691-50-2

Usage

Uses

Used in Pharmaceutical Industry:
N3-(4-methoxy-phenyl)-1H-[1,2,4]triazole-3,5-diamine is used as a pharmaceutical compound for its potential therapeutic applications. N³-(4-methoxy-phenyl)-1H-[1,2,4]triazole-3,5-diamine's antimicrobial, antifungal, and anticancer properties make it a valuable candidate for the development of new drugs to treat various diseases and conditions.
Used in Antimicrobial Applications:
N3-(4-methoxy-phenyl)-1H-[1,2,4]triazole-3,5-diamine is used as an antimicrobial agent for its ability to inhibit the growth of harmful microorganisms. This property can be utilized in the development of new antibiotics and antifungal medications to combat drug-resistant infections.
Used in Antifungal Applications:
N3-(4-methoxy-phenyl)-1H-[1,2,4]triazole-3,5-diamine is used as an antifungal agent for its potential to treat fungal infections. Its antifungal properties can be harnessed in the development of new medications to address the growing issue of drug-resistant fungal pathogens.
Used in Anticancer Applications:
N3-(4-methoxy-phenyl)-1H-[1,2,4]triazole-3,5-diamine is used as an anticancer agent for its potential to inhibit the growth and progression of cancer cells. N³-(4-methoxy-phenyl)-1H-[1,2,4]triazole-3,5-diamine's ability to target cancer cells makes it a promising candidate for the development of new chemotherapeutic drugs and cancer treatment strategies.
Used in Research and Development:
N3-(4-methoxy-phenyl)-1H-[1,2,4]triazole-3,5-diamine is used as a research compound for its potential in the development of novel pharmaceuticals. Its unique structure and biological activities make it an interesting target for further research and development in the fields of medicinal chemistry and drug discovery.

Upstream product

• 2284-20-0 4-Methoxyphenyl isothiocyanate 
• 57494-95-8 1-p-methoxyphenyl-2,4-dithiobiuret 
• 196877-92-6 1-[(3,5-Dimethyl-pyrazol-1-yl)-imino-methyl]-3-(4-methoxy-phenyl)-thiourea 

Relevant academic research and scientific papers

Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore

High-throughput screening for inhibitors of the human metalloprotease, methionine aminopeptidase-2 (MetAP2), identified a potent class of 3-anilino-5-benzylthio-1,2,4-triazole compounds. Efficient array and interative synthesis of triazoles led to rapid SAR development around the aniline, benzylthio, and triazole moeities. Evaluation of these analogs in a human MetAP2 enzyme assay led to the identification of several inhibitors with potencies in the 50-100 picomolar range. The deleterious effects on inhibitor potency by methylation of the anilino-triazole nitrogens, as well as the X-ray crystal structure of triazole 102 bound in the active site of MetAP2, confirm the key interactions between the triazole nitrogens, the active site cobalt atoms, and the His-231 side-chain. The structure has also provided a rationale for interpreting SAR within the triazole series. Key aniline (2-isopropylphenyl) and sulfur substituents (furanylmethyl) identified in the SAR studies led to the identification of potent inhibitors (103 and 104) of endothelial cell proliferation. Triazoles 103 and 104 also exhibited dose-dependent activity in an aortic ring tissue model of angiogenesis highlighting the potential utility of MetAP2 inhibitors as anticancer agents.

1-(N-arylthiocarbamoyl)amidino-3,5-dimethyl pyrazoles - Preparation and use in heterocycle synthesis

On reaction with α-haloketones or hydrazine, 1-(N-arylthiocarbamoyl)amidino-3,5-dimethylpyrazoles (1) afford 2,4-diaminothiazoles and 3,5-diamino-1,2,4-triazoles in good yield. A convenient route to 1 is also reported.