166948-47-6

Basic information

• Product Name: (S)-4-benzyl-3-((R)-2-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)propanoyl)oxazolidin-2-one
• Synonyms: (S)-4-benzyl-3-((R)-2-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)propanoyl)oxazolidin-2-one;(4S)-3-[(2R)-2-[(2R)-2-(2,4-Difluorophenyl)-2-oxiranyl]-1-oxopropyl]-4-(phenylmethyl)-2-oxazolidinone;(4S)-3-[(2R)-2-[(2R)-2-(2,4-Difluorophenyl)oxiranyl]-1-oxopropyl]-4-benzyl-2-oxazolidinone
• CAS NO: 166948-47-6
• Molecular Formula: C21H19F2NO4
• Molecular Weight: 387.38
• Product Categories: Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 166948-47-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 531.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.370
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• PKA: -2.36±0.40(Predicted)
• CAS DataBase Reference: (S)-4-benzyl-3-((R)-2-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)propanoyl)oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-benzyl-3-((R)-2-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)propanoyl)oxazolidin-2-one(166948-47-6)
• EPA Substance Registry System: (S)-4-benzyl-3-((R)-2-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)propanoyl)oxazolidin-2-one(166948-47-6)

Safety Data

• Hazardous Substances Data: 166948-47-6(Hazardous Substances Data)

Usage

Uses

Intermediate in the preparation of Albaconazole.

Upstream product

• 102429-07-2 2-bromo-2',4'-difluoroacetophenone 
• 131685-53-5 (S)-4-benzyl-3-propionyl-2-oxazolidinone 

Downstream Products

• 166948-48-7 (2R,3R)-3-[3-(2,4-difluorophenyl)-3,4-epoxy-2-methyl]butanoic acid 

Relevant articles and documents

Carbon analogs of antifungal dioxane-triazole derivatives: Synthesis and in vitro activities

A new series of triazole compounds possessing a carbon atom in place of a sulfur atom were efficiently synthesized and their in vitro antifungal activities were investigated. The carbon analogs showed excellent in vitro activity against Candida, Cryptococcus, and Aspergillus species. The MICs of compound 1c against C. albicans ATCC24433, C. neoformans TIMM1855, and A. fumigatus ATCC26430 were 0.016, 0.016, and 0.125 μg/mL, respectively (MICs of fluconazole: 0.5, >4, and >4 μg/mL; MICs of itraconazole: 0.125, 0.25, and 0.25 μg/mL).