166952-77-8

Upstream product

• 1197-09-7 1-(3,4-dihydroxyphenyl)ethan-1-one 
• 96-32-2 bromoacetic acid methyl ester 
• 96-34-4 methyl chloroacetate 

Downstream Products

• 214057-60-0 [2-methoxycarbonylmethoxy-5-(2-methyl-[1,3]dioxolan-2-yl)-phenoxy]-acetic acid methyl ester 
• 113393-36-5 1-[3,4-bis(2-hydroxy-ethoxy)-phenyl]-ethanone 
• 338740-52-6 3-[3,4-bis-(2-hydroxy-ethoxy)-phenyl]-3-oxo-propionic acid ethyl ester 
• 338740-53-7 3-[3,4-bis-(2-hydroxy-ethoxy)-benzoyl]-chromen-2-one 
• 338740-54-8 3-[3,4-bis-(2-hydroxy-ethoxy)-benzoyl]-7-methoxy-chromen-2-one 
• 338740-55-9 3-[3,4-bis-(2-hydroxy-ethoxy)-benzoyl]-5,7-dimethoxy-chromen-2-one 
• 338740-57-1 methanesulfonic acid 2-[2-(2-methanesulfonyloxyethoxy)-5-(2-oxo-2H-chromene-3-carbonyl)-phenoxy]-ethyl ester 
• 338740-58-2 methanesulfonic acid 2-[2-(2-methanesulfonyloxyethoxy)-5-(7-methoxy-2-oxo-2H-chromene-3-carbonyl)-phenoxy]-ethyl ester 
• 338740-59-3 methanesulfonic acid 2-[5-(5,7-dimethoxy-2-oxo-2H-chromene-3-carbonyl)-2-(2-methanesulfonyloxyethoxy)-phenoxy]-ethyl ester 
• 349458-64-6 ({2-[2-[2-(bis-tert-butoxycarbonylmethyl-amino)-ethoxy]-5-(2-oxo-2H-chromene-3-carbonyl)-phenoxy]-ethyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester 
• 349458-65-7 ({2-[2-[2-(bis-tert-butoxycarbonylmethyl-amino)-ethoxy]-5-(7-methoxy-2-oxo-2H-chromene-3-carbonyl)-phenoxy]-ethyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester 
• 349458-66-8 ({2-[2-[2-(bis-tert-butoxycarbonylmethyl-amino)-ethoxy]-5-(5,7-dimethoxy-2-oxo-2H-chromene-3-carbonyl)-phenoxy]-ethyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester 
• 113393-37-6 2-[2-(2-hydroxy-ethoxy)-5-(2-methyl-[1,3]dioxolan-2-yl)-phenoxy]-ethanol 
• 338740-56-0 3-[3,4-bis-(2-hydroxy-ethoxy)-benzoyl]-7-diethylamino-chromen-2-one 

Relevant academic research and scientific papers

Synthesis and in vitro analysis of novel dihydroxyacetophenone derivatives with antimicrobial and antitumor activities

Herein we report a feasible study concerning the design, syntheses and in vitro antimicrobial and antitumoral activities of some novel compounds with dihydroxyacetophenone (DA) moiety. An efficient and general method for the preparation of diazine with dihydroxyacetophenone (DDA) skeleton under conventional thermal heating (TH), microwave (MW) and ultrasounds (US) irradiation is presented. Antimicrobial and antitumoral tests prove that some dihydroxyacetophenone compounds (the brominated derivatives BrDA 3) have a significant biological activity. It is also to be pointed out that, basically all the dihydroxyacetophenone derivatives proved to have a powerful antibacterial activity against drug resistant Gram-negative strain Pseudomonas aeruginosa ATCC 27853. Of particular interest could be the excellent antibacterial activity of our dihydroxyacetophenone compounds against drug resistant Gram-negative strain Pseudomonas aeruginosa.

Novel polyaminocarboxylate chelates derived from 3-aroylcoumarins

We have devised efficient reaction pathways to attach aminopolycarboxylate subunits to the 3-aroylcoumarin chromophore. Two series of compounds were thus prepared in which the chelating arms were directly bonded to the coumarin ring (series A) or to the 3

Heterocyclic derivatives

Compounds of formula I STR1 and metabolically labile esters and amides thereof, and pharmaceutically acceptable salts thereof, in which R13, M2, X1, Z1, Z1a, X2 and A1 have the meanings given in the specification. The compounds are useful as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa. Novel intermediates are also disclosed.

Heterocyclic derivatives

Compounds of formula I STR1 and metabolically labile esters and amides thereof, and pharmaceutically acceptable salts thereof, in which R13, M2, X1, Z1, Z1a, X2 and A1 have the meanings given in the specification. The compounds are useful as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa. Intermediates are also disclosed.