166964-11-0

Basic information

• Product Name: 4-(4-Methoxyphenyl)-3-methylisoxazol-5-amine
• Synonyms: 5-Amino-4-(4-methoxyphenoxy)-3-methylisoxazole
• CAS NO: 166964-11-0
• Molecular Formula: C11H12N2O2
• Molecular Weight: 220.22
• Mol File: 166964-11-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-Methoxyphenyl)-3-methylisoxazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Methoxyphenyl)-3-methylisoxazol-5-amine(166964-11-0)
• EPA Substance Registry System: 4-(4-Methoxyphenyl)-3-methylisoxazol-5-amine(166964-11-0)

Safety Data

• Hazardous Substances Data: 166964-11-0(Hazardous Substances Data)

Usage

General Description

4-(4-Methoxyphenyl)-3-methylisoxazol-5-amine, also known as M4MIA, is a chemical compound that belongs to the class of isoxazole amines. It is a synthetic compound that has been studied for its potential pharmacological properties, including its ability to act as an antagonist at the glutamate receptor. M4MIA has been shown to exhibit neuroprotective effects in certain experimental models, making it a potential candidate for the treatment of neurological disorders such as epilepsy and neurodegenerative diseases. Its structure and properties make it an interesting target for further research in the field of medicinal chemistry and drug development.

Upstream product

• 150-76-5 4-methoxy-phenol 
• 33084-49-0 4-bromo-3-methyl-5-aminoisoxazole 

Relevant articles and documents

SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN

Sulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided. The sulfonamides have formula I: STR1 in which Ar 1 is a 3-or 5-isoxazolyl and Ar. sup.2 is selected from among alkyl, including straight and branched chains, aromatic rings, fused aromatic rings and heterocyclic rings, including 5-membered heterocycles with one, two or more heteroatoms and fused ring analogs thereof and 6-membered rings with one, two or more heteroatoms and fused ring analogs thereof. Ar 2 is preferably thiophenyl, furyl, pyrrolyl, naphthyl, and phenyl. Compounds in which Ar. sup.1 is a 4-halo-substituted isoxazole are more active than the corresponding alkyl-substituted compound and compounds in which Ar 1 is substituted at this position with a higher alkyl tend to exhibit greater affinity for ET B receptors than the corresponding lower alkyl-substituted compound.