166974-24-9

Upstream product

• 212072-23-6 4,6-Dichloro-3-[2-oxo-1-phenyl-piperidin-(3E)-ylidenemethyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole-2-carboxylic acid methyl ester 
• 7661-20-3 N-5-bromovaleryl-aniline 
• 153435-97-3 4,6-dichloro-3-formyl-1-(2-trimethylsilanylethoxymethyl)-indole-2-carboxylic acid ethyl ester 
• 153435-96-2 ethyl-3-formyl-4,6-dichloro-indole-2-carboxylate 
• 62-53-3 aniline 
• 91247-37-9 δ-Hydroxy-valeranilid 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 

Relevant academic research and scientific papers

Indole derivatives

This invention relates to compounds of formula STR1 or a salt, or metabolically labile ester thereof wherein R represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethyl, trifluoromethoxy, nitro, cya

Unusual synthesis of new glycine antagonists via sequential aldol condensation-lactonization-elimination reaction

Compounds 2 and 3 were designed in order to probe the North-East region of the strichnine-insensitive glycine binding site of the NMDA receptor. The two products were obtained readily by a tandem aldol condensation- lactonization-elimination step which af