16704-78-2

Basic information

• Product Name: (3-hydroxy-p-tolyl)urea
• Synonyms: (3-hydroxy-p-tolyl)urea;N-(3-Hydroxy-4-methylphenyl)urea;Einecs 240-756-0
• CAS NO: 16704-78-2
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.1772
• EINECS: 240-756-0
• Mol File: 16704-78-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 315 °C at 760 mmHg
• Flash Point: 144.3 °C
• Appearance: /
• Density: 1.335 g/cm³
• Vapor Pressure: 0.000243mmHg at 25°C
• Refractive Index: 1.663
• CAS DataBase Reference: (3-hydroxy-p-tolyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: (3-hydroxy-p-tolyl)urea(16704-78-2)
• EPA Substance Registry System: (3-hydroxy-p-tolyl)urea(16704-78-2)

Safety Data

• Hazardous Substances Data: 16704-78-2(Hazardous Substances Data)

Usage

General Description

(3-hydroxy-p-tolyl)urea, also known as 3-HPTU, is an organic compound with the chemical formula C8H10N2O2. It is derived from the reaction of p-toluidine with phosgene. 3-HPTU is a white crystalline solid that is sparingly soluble in water but more soluble in organic solvents. It is used in the synthesis of various pharmaceuticals and agricultural chemicals. Additionally, 3-HPTU has been studied for its potential as a corrosion inhibitor and as a ligand in coordination chemistry. Overall, (3-hydroxy-p-tolyl)urea has various industrial and research applications due to its versatile chemical properties.

InChI:InChI=1/C8H10N2O2/c1-5-2-3-6(4-7(5)11)10-8(9)12/h2-4,11H,1H3,(H3,9,10,12)

Upstream product

• 5428-54-6 2-methyl-5-nitrophenol 
• 590-28-3 potassium cyanate 
• 2835-95-2 amino-4 hydroxy-2 toluene 

Downstream Products

• 933045-88-6 ethyl 2-(3-hydroxy-4-methylphenylamino)oxazole-4-carboxylate 
• 57839-17-5 [2-(3-Chloro-4-methylamino-phenylamino)-5-hydroxy-4-methyl-phenyl]-urea 
• 57839-18-6 {2-[3-Chloro-4-(2-hydroxy-ethylamino)-phenylamino]-5-hydroxy-4-methyl-phenyl}-urea 
• 56330-93-9 {6-[(Z)-3-Chloro-4-(2-hydroxy-ethylamino)-phenylimino]-4-methyl-3-oxo-cyclohexa-1,4-dienyl}-urea 
• 56330-88-2 (6-{[3-chloro-4-(methylamino)phenyl]imino}-4-methyl-3-oxocyclohexa-1,4-dien-1-yl)urea 
• 55303-62-3 C₁₉H₂₃N₅O₃ 
• 55302-71-1 C₁₈H₂₂N₄O₄ 

Relevant articles and documents

COMPOUNDS AND METHODS FOR THE TREATMENT OF VIRUSES AND CANCER

The present invention relates to compounds according to the formula I: Where Ra is H or an optionally OH-substituted C1-C3 alkyl; R1 is OR1, an optionally substituted C4-12 carbocyclic group which may be saturated or unsaturated (including aromatic) or an optionally substituted heterocyclic group; R1 is an optionally substituted C1-C14 hydrocarbyl group or an optionally substituted heterocyclic group;; R2 , R3 and R4 are each independently H, an optionally substituted C1-C4 alkyl group (preferably CH3, CH2CH3 or CF3), halogen (preferably F, Cl, Br), OR, CN, NO2, a C1-C6 thioether, a C1-C6 thioester group, an optionally substituted CO2R group, an optionally substituted COR group or an optionally substituted OCOR group (preferably R4 is H); R is H or an optionally substituted C1-C6 alkyl group; RHET is an optionally substituted heterocyclic group; and pharmaceutically acceptable salts, solvates or polymorphs thereof.

Nitrated coupler compounds useful in direct dyeing and simultaneous oxidation and direct dyeing of keratinic fibers

A cosmetic composition for application to the hair contains either (a) at least one compound having the formula STR1 wherein: R is hydrogen, alkyl or halogen; and R' is hydrogen, alkyl, hydroxyalkyl, carbamylalkyl, mesylaminoalkyl, aminoalkyl, acylaminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, piperidinoalkyl, morpholinoalkyl, carbamoyl, acyl or carbalkoxy; or (b) at least one of said compounds having formula I above and at least one benzene or heterocyclic oxidation base. The invention also relates to new couplers of formula I as well as to new indo compounds which result from the coupling of said compounds with an oxidation base. These cosmetic compositions for application to the hair are useful in direct dyeing, oxidation dyeing or simultaneous oxidation and direct dyeing of said hair.