16704-79-3

Basic information

• Product Name: 1-(3-HYDROXY-4-METHYLPHENYL)THIOUREA
• Synonyms: 1-(3-HYDROXY-4-METHYLPHENYL)THIOUREA
• CAS NO: 16704-79-3
• Molecular Formula: C₈H₁₀N₂OS
• Molecular Weight: 182.24
• Mol File: 16704-79-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 202 °C
• Boiling Point: 340.3±52.0 °C(Predicted)
• Appearance: /
• Density: 1.377±0.06 g/cm3(Predicted)
• PKA: 9.71±0.10(Predicted)
• CAS DataBase Reference: 1-(3-HYDROXY-4-METHYLPHENYL)THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-HYDROXY-4-METHYLPHENYL)THIOUREA(16704-79-3)
• EPA Substance Registry System: 1-(3-HYDROXY-4-METHYLPHENYL)THIOUREA(16704-79-3)

Safety Data

• Hazardous Substances Data: 16704-79-3(Hazardous Substances Data)

Usage

General Description

1-(3-Hydroxy-4-methylphenyl)thiourea is a chemical compound with the molecular formula C8H10N2OS. It is a thiourea derivative that contains a hydroxy-substituted methylphenyl group. 1-(3-HYDROXY-4-METHYLPHENYL)THIOUREA has been studied for various biological activities, including its potential as an antioxidant and anti-inflammatory agent. Its ability to scavenge free radicals and inhibit inflammatory processes makes it a promising candidate for therapeutic use in conditions such as rheumatoid arthritis and other inflammatory disorders. Additionally, 1-(3-hydroxy-4-methylphenyl)thiourea has also been investigated for its potential as an environmental pollutant scavenger due to its ability to bind and remove heavy metal ions from polluted water.

Upstream product

• 2835-95-2 amino-4 hydroxy-2 toluene 
• 1147550-11-5 ammonium thiocyanate 
• 130264-16-3 5-amino-o-cresol hydrochloride 

Downstream Products

• 933045-66-0 ethyl 2-(4-methyl-3-(3-methylbut-2-enyloxy)phenylamino)thiazole-4-carboxylate 
• 933045-63-7 2-methyl-5-(4-methylthiazol-2-ylamino)phenol 
• 1300643-98-4 C₁₀H₁₀N₂O₂S 
• 1300643-94-0 C₂₄H₃₅N₃O₅S₃ 
• 1300643-90-6 C₁₆H₂₃N₃O₄S 
• 1300643-84-8 C₂₄H₂₅N₃O₆S 
• 1187668-75-2 2-methyl-5-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenol 

Relevant articles and documents

Proteome interrogation using nanoprobes to identify targets of a cancer-killing molecule

We report a generic approach for identification of target proteins of therapeutic molecules using nanoprobes. Nanoprobes verify the integrity of nanoparticle- bound ligands in live cells and pull down target proteins from the cellular proteome, providing very important information on drug targets and mechanisms of action. As an example, target proteins as R-tubulin and HSP 90 have been identified and validated.

HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE IN CANCER TREATMENT

Provided herein are novel heteroaryl compounds, compositions comprising the compounds, and methods of treatment or prevention comprising administration of the compounds. The compounds are effective in the targeting of cells defective in the von Hippel-Lindau gene and in inducing autophagic cell death. The methods are directed to treating or preventing diseases such as cancer, and in particular cancers resulting from von Hippel-Lindau disease. The compounds of the invention may be administered in combination with another therapeutic agent.