167074-41-1Relevant academic research and scientific papers
Total synthesis of a Streptococcus pneumoniae serotype 12F CPS repeating unit hexasaccharide
Seeberger, Peter H.,Pereira, Claney L.,Govindan, Subramanian
supporting information, p. 164 - 173 (2017/02/15)
The Gram-positive bacterium Streptococcus pneumoniae causes severe disease globally. Vaccines that prevent S. pneumoniae infections induce antibodies against epitopes within the bacterial capsular polysaccharide (CPS). A better immunological understanding
Synthesis of the trisaccharide outer core fragment of Burkholderia cepacia pv. vietnamiensis lipooligosaccharide
Bedini, Emiliano,Cirillo, Luigi,Parrilli, Michelangelo
experimental part, p. 24 - 32 (2012/03/11)
The synthesis of β-Gal-(1→3)-α-GalNAc-(1→3)-β- GalNAc allyl trisaccharide as the outer core fragment of Burkholderia cepacia pv. vietnamiensis lipooligosaccharide was accomplished through a concise, optimized, multi-step synthesis, having as key steps three glycosylations, that were in-depth studied performing them under several conditions. The target trisaccharide was designed with an allyl aglycone in order to open a future access to the conjugation with an immunogenic protein en route to the development of a synthetic neoglycoconjugate vaccine against this Burkholderia pathogen.
